WANG Yonggang, LI Caihong, YU Yuanwang, et al. Clinical Observation on Zhishe Tongluo Capsule(蛭蛇通络胶囊) Combined with West Medicine Treating 78 Cases of Ischemic Stroke Convalescence Phase[J]. Journal of Traditional Chinese Medicine2015, 56(19): 1659-1662.
WANG Yonggang, LI Caihong, YU Yuanwang, et al. Clinical Observation on Zhishe Tongluo Capsule(蛭蛇通络胶囊) Combined with West Medicine Treating 78 Cases of Ischemic Stroke Convalescence Phase[J]. Journal of Traditional Chinese Medicine2015, 56(19): 1659-1662.DOI: 10.13288/j.11-2166/r.2015.19.011.
Clinical Observation on Zhishe Tongluo Capsule(蛭蛇通络胶囊) Combined with West Medicine Treating 78 Cases of Ischemic Stroke Convalescence Phase
Objective To observe the clinical effect of Zhishe Tongluo Capsule combined with west medicine treating ischemic stroke convalescence phase patients of Qi deficiency and blood stasis syndrome. Methods Totally156 ischemic stroke convalescence phase patients of Qi deficiency and blood stasis syndrome were randomly divided into control group and treatment group
each of 78 cases. Control group were given basic standard treatment and thirdlevel rehabilitation program. Treatment group were added oral Zhishe Tongluo Capsule
4 capsules each time( 0. 5 g each capsules)
3 times a day. Both groups were treated for 8 weeks. Observe blood lipid including total cholesterol( TC)
triglyceride( TG)
high density lipoprotein cholesterol( HDL-C) and low density lipopro tein cholesterol( LDL-C) level in both groups before and after treatment. Evaluate therapeutic effect adopting Chinese medicine syndrome scores
National Institute of Health stroke scale( NIHSS) and Modified Rankin Scale before treatment and 2
4
8 weeks after treatment. Results Total effective rate in treatment group was 79. 22%
67. 11% in control group( P < 0. 05). TC
TG and LDL-C in both groups were decreased after treatment
while HDL-C increased( P < 0. 05 or P < 0. 01). The decrease of LDL-C and increase of HDL-C in treatment group was significant compared with that in control group after treatment( P < 0. 05). Scores of Chinese medicine syndrome
NIHSS and Modified Rankin Scale in treatment group were decreased after 4 and 8 weeks treatment( P < 0. 05 or P < 0. 01). Scores in control group were decreased after 8 weeks treatment( P < 0. 05). Scores of Chinese medicine syndrome and NIHSS in treatment group were lower than those in control group after 4 and 8 weeks treatment( P < 0. 05). Scores of Modified Rankin Scale in treatment group decreased more significantly than those in control group after 8 weeks treatment( P < 0. 05).Conclusion Zhishe Tongluo Capsule combined with west medicine could decrease blood lipid effectively
improve clinical symptoms and recover nerves function and activities of daily living of ischemic stroke convalescence phase patients of Qi deficiency and blood stasis syndrome.
Effects of Tongluo Fuzheng Decoction (通络扶正汤) as an Adjunctive Therapy on Coagulation and Vascular Endothelial Function in Patients with Ischemic Stroke of the Acute Stage with Wind-Phlegm and Blood Stasis Syndrome
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