Tumor microenvironment refers to a local external environment inseparable from the process of proliferation

invasion and metastasis of tumor cells. Just like normal extracellular environment

tumor microenvironment is a complex micro eco-network

in which low oxygen

low p H value and chronic inflammation are important factors to lead tumor tissues to abnormal proliferation

metastasis and relapsing

and it is similar to traditional Chinese medicine（ TCM） microenvironment caused by blending insufficiency of the spleen

phlegm

stasis

cancer poison and other pathological factors. It suggests that TCM etiology and pathogenesis of tumor may be explored from the point of microenvironment. By studying the relationship between the microenvironment and TCM etiology and pathogenesis of tumor

reference could be provided for using tumor microenvironment theory in clinical to guide TCM anti-tumor therapy.