Objective To observe the clinical characteristics of menopausal insomnia（ MI） with kidney deficiency and liver depression syndrome. Methods Social demographic characteristics as well as sleep and menstrual status of 602 MI patients were studied by adopting clinical epidemiological investigation methods and neuropsychological evaluation scale. Serum levels of estradiol（ E2）

follicle stimulating hormone（ FSH） and luteinizing hormone（ LH）were detected. Clinical characteristics of MI with kidney deficiency and liver depression syndrome were analyzed by applying single and multi-factor non-conditional logistic regression method. Results There were 364 cases with kidney deficiency and liver depression syndrome in 602 MI patients

and 238 cases without kidney deficiency and liver depression syndrome. After excluding the influence of social demographic characteristics factors

such as age

type A personality

exercises

quality protein and cholesterol intake

religion

hobbies and interests

social support and connection

etc.

there were still significant differences in Pittsburgh Sleep Quality Index

scores of Self-rating Depression Scale and Self-Rating Anxiety Scale

sleep latency

total sleep time

menstrual status

and serum levels of E2 and FSH between patients with and without kidney deficiency and liver depression syndrome（ P < 0. 05 or P <0. 01）; the correlation strength OR（ 95% confidence interval） were 1. 64（ 1. 08- 2. 49）

1. 77（ 1. 06- 2. 95）

1. 65（ 1. 00- 2. 70）

1. 41（ 1. 08- 1. 85）

1. 68（ 1. 06- 2. 68）

1. 71（ 1. 07- 2. 73）

2. 56（ 1. 74- 3. 78）

and 2. 69（ 1. 82- 3. 98） respectively. Conclusion Most MI patients with kidney deficiency and liver depression syndrome were postmenopausal women

with significant depression and anxiety status

low sleep quality including obvious difficulty falling asleep and short sleep time

and disorder of serum levels of sex hormone（ mainly low E2 and high FSH level）.