Objective To observe the impact of modified Shugan Yishen Fang on immune function and quality of life of patients with triple negative breast cancer（ TNBC）. Methods Totally 30 TNBC patients were given modified Shugan Yishen Fang after modified radical mastectomy

one dose every day

for 2 months. Meanwhile

they were given chemotherapy regimen of TAC or AC weekly T for 6 to 8 weeks. The improvement in quality of life and symptoms were observed. Changes in the levels of regulatory T Cells

cytotoxic T cells

suppressor T cells and natural killer cells before and after treatment were compared. Results Levels of regulatory T Cells and suppressor T cells decreased

while cytotoxic T cells and natural killer cells increased after treatment（ P < 0. 05）. Scores of eight dimensions in the Medical Outcomes Study 36-Item Short Form Health Survey（ SF-36） increased（ P < 0. 05）. The occurring ratio of hectic fever

night sweat

bone pain and insomnia decreased（ P < 0. 05）. Conclusion Modified Shugan Yishen Fang combined with radiotherapy and chemotherapy could promote immunologic responsibility

reduce immunosuppression effect

improve quality of life

and relieve symptoms in TNBC patients.