Impact of Shengqing Jiangzhuo Fang（升清降浊方） on Inflammatory Factors of Rats with Chronic Renal Failure

FU Guiping; LI Qingyao; WANG Dongya; WANG Xia; DAI Caihua; ZHONG Dan; WANG Juan; LIU Simei

doi:10.13288/j.11-2166/r.2015.20.014

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Impact of Shengqing Jiangzhuo Fang（升清降浊方） on Inflammatory Factors of Rats with Chronic Renal Failure

更新时间：2021-11-17

- Impact of Shengqing Jiangzhuo Fang（升清降浊方） on Inflammatory Factors of Rats with Chronic Renal Failure
- Journal of Traditional Chinese Medicine Vol. 56, Issue 20, Pages: 1763-1766(2015)
- 作者机构：
  
  井冈山大学临床医学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2015.20.014
  CLC： R285.5
- Published：2015
- 稿件说明：
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[1]傅贵平,李庆耀,王冬芽,王霞,戴彩华,钟丹,王娟,刘思美.升清降浊方对慢性肾功能衰竭大鼠炎症因子的影响[J].中医杂志,2015,56(20):1763-1766.

FU Guiping, LI Qingyao, WANG Dongya, et al. Impact of Shengqing Jiangzhuo Fang（升清降浊方） on Inflammatory Factors of Rats with Chronic Renal Failure[J]. Journal of Traditional Chinese Medicine2015, 56(20): 1763-1766.
[1]傅贵平,李庆耀,王冬芽,王霞,戴彩华,钟丹,王娟,刘思美.升清降浊方对慢性肾功能衰竭大鼠炎症因子的影响[J].中医杂志,2015,56(20):1763-1766. DOI： 10.13288/j.11-2166/r.2015.20.014.

FU Guiping, LI Qingyao, WANG Dongya, et al. Impact of Shengqing Jiangzhuo Fang（升清降浊方） on Inflammatory Factors of Rats with Chronic Renal Failure[J]. Journal of Traditional Chinese Medicine2015, 56(20): 1763-1766. DOI： 10.13288/j.11-2166/r.2015.20.014.

摘要

目的探讨升清降浊方治疗慢性肾功能衰竭的可能作用机制。方法 160只SD大鼠随机分为空白组、肾衰模型组、包醛氧组、升清降浊方组

每组40只。除空白组外其余各组采用大鼠5/6肾切除方法制备慢性肾功能衰竭模型

包醛氧组给予包醛氧淀粉每次0.04 g灌胃

每日1次;升清降浊方组给予升清降浊方溶液（浓度为1 g/ml）1ml/100 g灌胃

每日1次;空白组、肾衰模型组给予等量生理盐水灌胃

各组灌胃均28天。采集各组大鼠血清样本进行肾功能检测

包括肌酐（SCr）、尿素氮（BUN）和尿酸（UA）;生化指标检测包括白细胞介素1（IL-1）、白细胞介素6（IL-6）和肿瘤坏死因子α（TNF-α）;并对大鼠肾组织进行病理切片观察。结果肾衰模型组大鼠BUN、UA、TNF-α较空白组明显升高（P<0.05或P<0.01）。包醛氧组、升清降浊方组大鼠UA、TNF-α较肾衰模型组降低（P<0.05或P<0.01）;升清降浊方组UA、TNF-α较包醛氧组降低更显著（P<0.05或P<0.01）。病理结果显示

升清降浊方组大鼠代偿性肥大肾小球充血

肾小管上皮水肿明显

局灶有肾小管上皮脱落可见

但肾间质炎细胞浸润密度减少

且肾小球萎缩明显较其他组减少。结论升清降浊方可能通过调控炎症因子IL-6和TNF-α水平

从而阻断慢性肾功能衰竭病情发展

改善肾功能。

Abstract

Objective To explore the possible mechanism of Shengqing Jiangzhuo Fang in the treatment of chronic renal failure（ CRF）. Methods Totally 160 Sprague Dawley rats were randomly divided into blank group（ n =40）

CRF model group（ n = 40）

oxyamyli tectus group（ n = 40） and Shengqing Jiangzhuo Fang group（ n = 40）.CRF models were established in every group adopting the method of 5 /6 nephrectomy except in blank group. Oxyamyli tectus group was given 0. 04 g of oxyamyli tectus aldehydum by gavage once every day. Shengqing Jiangzhuo Fang group was given 1 ml /100 g of Shengqing Jiangzhuo Fang solution（ concentration 1 g / ml） by gavage once every day.Blank group and CRF model group were given equivalent normal saline by gavage. All the treatments were lasted for28 days. Serum samples of rats were collected in each group. Renal function

including creatinine（ SCr）

urea nitrogen（ BUN） and uric acid（ UA）

and biochemical indexes

including interleukin1（ IL-1）

interleukin6（ IL-6）and tumor necrosis factorα（ TNFα） were detected. The pathological sections of rats’ renal tissues were observed.Results BUN

UA and TNF-α of rats in CRF model group increased more significantly than those in blank group（ P < 0. 05 or P < 0. 01）. UA and TNF-α of rats in oxyamyli tectus group and Shengqing Jiangzhuo Fang group were lower than those in CRF model group（ P < 0. 05 or P < 0. 01）. UA and TNF-α in Shengqing Jiangzhuo Fang group decreased more significantly than those in oxyamyli tectus group（ P < 0. 05 or P < 0. 01）. Pathological sections showed compensatory hypertrophy glomerulus hyperemia

significant renal tubular epithelium edema

visible focal renal tubular epithelium exuviation

less renal interstitium inflammatory cells infiltration density in rats in Shengqing Jiangzhuo Fang group

and atrophic glomerulus in this group was much less than those in other groups. Conclusion Shengqing Jiangzhuo Fang might block the development of CRF and improve renal function by regulating inflammatory factors of IL-6 and TNF-α.

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