Impact of Yigong Powder（异功散） on Mice with Iron Metabolism Disorder Mediated by Lipopolysaccharide

ZHENG Qin; GUAN Yu; WANG Zhicheng; WANG Jianying; PU Yiqiong; WANG Guohua; ZHANG Xiaofeng; XIA Jing; CUI Lele; LUO Meihong

doi:10.13288/j.11-2166/r.2015.20.015

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Impact of Yigong Powder（异功散） on Mice with Iron Metabolism Disorder Mediated by Lipopolysaccharide

更新时间：2021-11-17

- Impact of Yigong Powder（异功散） on Mice with Iron Metabolism Disorder Mediated by Lipopolysaccharide
- Journal of Traditional Chinese Medicine Vol. 56, Issue 20, Pages: 1767-1770(2015)
- 作者机构：
  
  1. 上海中医药大学附属上海市中医医院
  2. 复旦大学附属华山医院
  3. 上海中医药大学药学院
  4. 上海中医药大学附属曙光医院宝山分院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2015.20.015
  CLC： R285.5
- Published：2015
- 稿件说明：
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[1]郑秦,管宇,王志成,王健英,浦益琼,王国华,张晓峰,夏菁,崔乐乐,罗梅宏.异功散对脂多糖介导的小鼠铁代谢紊乱的影响[J].中医杂志,2015,56(20):1767-1770.

ZHENG Qin, GUAN Yu, WANG Zhicheng, et al. Impact of Yigong Powder（异功散） on Mice with Iron Metabolism Disorder Mediated by Lipopolysaccharide[J]. Journal of Traditional Chinese Medicine2015, 56(20): 1767-1770.
[1]郑秦,管宇,王志成,王健英,浦益琼,王国华,张晓峰,夏菁,崔乐乐,罗梅宏.异功散对脂多糖介导的小鼠铁代谢紊乱的影响[J].中医杂志,2015,56(20):1767-1770. DOI： 10.13288/j.11-2166/r.2015.20.015.

ZHENG Qin, GUAN Yu, WANG Zhicheng, et al. Impact of Yigong Powder（异功散） on Mice with Iron Metabolism Disorder Mediated by Lipopolysaccharide[J]. Journal of Traditional Chinese Medicine2015, 56(20): 1767-1770. DOI： 10.13288/j.11-2166/r.2015.20.015.

摘要

目的探讨异功散对炎症诱发的铁代谢紊乱的影响。方法 40只C57BL/6小鼠随机分为空白对照组、异功散组、脂多糖组、异功散加脂多糖组

每组10只。异功散组、异功散加脂多糖组给予异功散灌胃10.57 g/（kg·d）

空白对照组每只灌胃0.2 ml超纯水

各组均连续灌胃7天。第8天

脂多糖组和异功散加脂多糖组腹腔注射脂多糖1.5 mg/kg建立铁代谢紊乱模型

6h后处死所有小鼠。检测血常规、血清铁和肝组织铁含量、血清和肝组织白细胞介素6（IL-6）含量。结果各组小鼠血常规无明显变化

差异无统计学意义（P>0.05）。与空白对照组比较

脂多糖组小鼠血清铁降低

肝组织铁和血清、肝组织IL-6均明显上升（P<0.05）

而异功散组加脂多糖组较脂多糖组肝组织铁、血清和肝组织IL-6均明显下降（P<0.05）。结论异功散可改善脂多糖介导的急性炎症条件下的铁代谢紊乱

其机制可能与降低血清和肝组织IL-6有关。

Abstract

Objective To explore the impact of Yigong Powder on iron metabolism disorder induced by inflammation. Methods 40 C57 BL /6 mice were randomly divided into control group（ n = 10）

Yigong Powder group（ n = 10）

lipopolysaccharide group（ n = 10） and Yigong Powder combined with lipopolysaccharide group（ n = 10）.Yigong Powder group and Yigong Powder combined with lipopolysaccharide group were given 10. 57 g /（ kg ·d） of Yigong Powder by gavage. Control group was given 0. 2 ml of ultrapure water

all for seven days. On the eighth day

lipopolysaccharide group and Yigong Powder combined with lipopolysaccharide group were given 1. 5 mg / kg of lipopolysaccharide by intraperitoneal injection to establish iron metabolism disorder models. Six hours later

all mice were sacrificed. Blood routine

serum levels of iron and interleukin 6（ IL-6）

and content of iron and IL-6 in liver tissue were detected. Results Blood routine changed little in every group（ P > 0. 05）. Compared with control group

serum level of iron decreased

serum level of IL-6

as well as content of iron and IL-6 in liver tissue increased in lipopolysaccharide group（ P < 0. 05）. Compared with lipopolysaccharide group

iron content in liver tissue

as well as IL-6 in serum and liver tissue decreased in Yigong Powder combined with lipopolysaccharide group（ P < 0. 05）.Conclusion Yigong Powder could improve iron metabolism disorder mediated by lipopolysaccharide under acute inflammation. The mechanism may relate to decrease of IL-6 in serum and liver tissue.

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