Objective Through repetitive measurement experimental design method to compare the curative effect of Kangfu Xinye plus Shuangliao Houfengsan enema combined with mesalazine sustained release granules with simple mesalazine sustained release granules in the treatment of ulcer colitis patients. Methods Sixty patients with ulcerative colitis were randomly divided into experimental group and control group

with 30 cases in each group

The control group was treated with mesalazine sustained release granules

4 times a day

1 g each time; The treatment group were treated with 2. 2 g Shuangliao Houfengsan added into 50 ml Kangfu Xinye and 150 ml normal saline retention enema every night on the basis of the control group treatment. Two groups were treated continuously for 1 month

the main symptoms of diarrhea

pus and blood

abdominal pain

diarrhea

tenesmus would be scored before treatment and at 1

2

3 and 4 weeks after treatment

and repetitive measure variance analysis was taken. The symptom score was used as the dependent variable

observation time as time factor

and grouping as the independent variable were taken into repetitive measure variance analysis model. Results The results of diarrhea

purulent hematochezia

abdominal pain

tenesmus’ observation time data were not consistent with the globular hypothesis and were given adjustment. Adjusted and intergroup effect variance show that diarrhea

purulent hematochezia

abdominal pain

tenesmus scores decreased significantly over the observation

and the symptom score in the treatment group were significantly lower than those in the control group（ P < 0. 05）. Conclusion Both Kangfu Xinye plus Shuangliao Houfengsan enema combined with mesalazine sustained release granules and simple mesalazine sustained release granules can improve the clinical symptoms in patients with ulcerative colitis

and the combination therapy may have better improvement effect.