Objective To find endogenous metabolites of metabolic syndrome（ MS） patients of turbid phlegm stagnation type and to explore the serum metabonomics characteristics of MS turbid phlegm stagnation syndrome.Methods Totally 324 MS patients were collected. Serum samples of MS turbid phlegm stagnation type and non MS turbid phlegm stagnation type were randomly extracted（ 20 cases of each syndrome）. Eight healthy volunteers were for control. Detect and separate serum related metabolites of three groups by liquid chromatography-mass spectrometry technology. Make data processing adopting principal component analysis and partial least squares discriminant analysis. Find differential metabolites. Results Detected by metabonomics technologies

MS serum related metabolites included 23 types

such as sphingosine

4 5 docosahexaenoic acid

uric acid. MS turbid phlegm stagnation syndrome serum related metabolites included 27 types

such as phospholipid（ 20 ∶ 4）

palmitoyl L-carnitine

xanthine

phospholipid（ 18 ∶ 3）. Conclusion There was difference between MS turbid phlegm stagnation type and non MS turbid phlegm stagnation type patients’ serum metabolites. MS turbid phlegm stagnation type serum related metabolites included 27 types.