Objective To research the possible mechanism of Guben Fangxiao Yin in preventing and treating bronchial asthma. Methods Randomly divided 70 BALB / c mice into normal group

model group

Montelukast group

Guben Fangxiao Yin low

middle

high dose group

and the Guben Fangxiao Yin prevention group

with 10 in each. Mice in other groups except the normal group adopted ovum albumin sensitization and stimulation with respiratory syncytial virus infections method to established bronchial asthma model. The Montelukast group was given Montelukast Sodium Tablets 1. 5 mg /（ kg·d）. The Guben Fangxiao Yin low

middle

high dose group were respectively given Guben Fangxiao Yin 13. 5

27. 0

54. 0 g /（ kg·d）. Above groups were all given corresponding medicine from the 56 th day after starting to make model

once per day

for 28 days continuously. The Guben Fangxiao Yin prevention group was given Guben Fangxiao Yin 13. 5 g /（ kg·d）. Began to gavage from the first day of modelling

for 84 days.Used the middle lobe in the mice ’s right lungs in each group for HE dye. Examined the expression of lung tissue interleukin6（ IL-6）

interleukin8（ IL-8）

tumor necrosis factor α（ TNF-α） mRNA and the expression of STAT1 protein. Results HE dye results showed that normal structure of pulmonary lobule in the model group broke

the alveolar wall remarkably thickened

with hyperemia

edema and inflammatory cell infiltration

the airway wall thickened and lumen narrowed. Lung tissue of the mice in each medical groups only had slight inflammation lesion

remarkably decreasing compared with that of the model group. Compared with the normal group

the expression level of STAT1 protein and IL-6

IL-8

TNF-α mRNA of mouse lung tissue in the model group remarkably increased（ P <0. 05）; Compared with the model group

the expression of STAT1 protein and IL-6

IL-8

TNF-α mRNA of mice lung tissue in the Montelukast group

the Guben Fangxiao Yin low

middle

high dose group

and the Guben Fangxiao Yin prevention group remarkably decreased（ P < 0. 05）; The expression of TNF-α mRNA of mice lung tissue in the Montelukast group

the Guben Fangxiao Yin middle

high dose group

and the Guben Fangxiao Yin prevention group remarkably decreased（ P < 0. 01）. Conclusion Guben Fangxiao Yin could prevent and treat bronchial asthma

which may be related with inhibiting activating STAT1 protein in lung tissue and decreasing the expression of IL-6

IL-8

and TNF-α mRNA.