According to records in local chronicles

the authors established successive relationship of LI Zhongzi

MA Yuanyi and YOU Zai

with MA Yuanyi inheriting from LI Zhongzi

and YOU Zaijing inheriting from MA Yuanyi.The authors respectively chose medical works from three doctors and selected prescriptions from those. They also used the traditional philology method and the statistical method to contrastively analyze frequently-used herbs

four natures of drugs

the five flavours and channel tropism in clinical prescription and pharmacy of three doctors. Result showed that three doctors were good at using herbs with warm nature and emphasized sweet

bitter and pungent flavours of herbs and attached great importance to herbs of the spleen channel. The common therapy changed from warming spleen and stomach for dispelling cold to regulating the flow of vital energy and regulating the middle-jiao. Medical herbs were changed from primary warm nature to equal importance between cold and warm. According to similarity in medication of three doctors

the context of medical heritage is clear

but the trend of medication changes need further research.