Objective To observe therapeutic effects and safety of Huoxue Bitong Plaster（ 活血痹痛膏） treating lumbar osteoarthritis with blood-stasis and cold-dampness blocking collaterals syndrome. Methods Randomly divided 120 cases of patients suffering from lumbar osteoarthritis of blood-stasis and cold-dampness blocking collaterals syndrome into the treatment group and the control group

with 60 cases each. The treatment group was given Huoxue Bitong Plaster for application while the control group was given Goupi Plaster for application

both once per day

2weeks in total. Compared TCM scores

visual analogue scale（ VAS） and Oswestry disability index（ ODI） of patients in two groups. Compared the effect onset time and the curative effect durative effect of the two groups. After treatment

evaluated the clinical curative effect. Results There were 4 cases cured

23 cases remarkably effective

and 25 cases effective in the treatment group

while cured

remarkably effective and effective cases in the control group were 2

15 and 34. The efficacy of treatment group was remarkably superior to the control group（ P < 0. 05）.Integration of each symptom and total score of TCM syndrome

VAS scores and ODI indexes of patients in two groups after treatment all remarkably decreased（ P < 0. 05）; Integration and total scores of lumbar pain and morning stiffness

VAS scores and ODI indexes of the treatment group after treatment were all remarkably lower tan that of the control group（ P < 0. 05）. The onset time of lumbar pain

morning stiffness and ODI indexes of the treatment group was shorter than that of the control group（ P < 0. 05）. There were good effective duration effect in two groups

and the difference had no statistical significance（ P > 0. 05）. There was no remarkable adverse reaction during treatment.Conclusion The curative effects of Huoxue Bitong Plaster（ 活血痹痛膏） treating lumbar osteoarthritis with bloodstasis and cold-dampness blocking collaterals syndrome seems positive

with short onset time and good safety.