Clinical Observation on 40 Patients of Hashimoto Thyroiditis Treated with Shugan Qingre Fang（疏肝清热方）

ZHONG Xinchan; ZHENG Min; ZHANG Qiang; WANG Yanyan; ZHANG Dan; LI Yunhao; FAN Chaohua; YANG Hongjie

doi:10.13288/j.11-2166/r.2016.02.014

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Clinical Observation on 40 Patients of Hashimoto Thyroiditis Treated with Shugan Qingre Fang（疏肝清热方）

更新时间：2021-11-17

- Clinical Observation on 40 Patients of Hashimoto Thyroiditis Treated with Shugan Qingre Fang（疏肝清热方）
- Journal of Traditional Chinese Medicine Vol. 57, Issue 2, Pages: 145-148(2016)
- 作者机构：
  
  上海中医药大学附属岳阳中西医结合医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2016.02.014
  CLC： R259
- Published：2016
- 稿件说明：
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[1]钟欣婵,郑敏,张强,王燕燕,张丹,李昀昊,范朝华,杨宏杰.疏肝清热方治疗桥本甲状腺炎患者40例临床观察[J].中医杂志,2016,57(02):145-148.

ZHONG Xinchan, ZHENG Min, ZHANG Qiang, et al. Clinical Observation on 40 Patients of Hashimoto Thyroiditis Treated with Shugan Qingre Fang（疏肝清热方）[J]. Journal of Traditional Chinese Medicine2016, 57(2): 145-148.
[1]钟欣婵,郑敏,张强,王燕燕,张丹,李昀昊,范朝华,杨宏杰.疏肝清热方治疗桥本甲状腺炎患者40例临床观察[J].中医杂志,2016,57(02):145-148. DOI： 10.13288/j.11-2166/r.2016.02.014.

ZHONG Xinchan, ZHENG Min, ZHANG Qiang, et al. Clinical Observation on 40 Patients of Hashimoto Thyroiditis Treated with Shugan Qingre Fang（疏肝清热方）[J]. Journal of Traditional Chinese Medicine2016, 57(2): 145-148. DOI： 10.13288/j.11-2166/r.2016.02.014.

摘要

目的观察疏肝清热方治疗桥本甲状腺炎的临床疗效及可能作用机制。方法 80例桥本甲状腺炎患者随机分为治疗组和对照组各40例

并设健康对照组20例。治疗组给予疏肝清热方中药复方颗粒剂

每日1剂;对照组给予左甲状腺素钠片

每日1次

每次25μg

两组均连续口服12周。健康对照组不进行任何药物治疗。治疗后判定两组临床疗效

并观察两组患者治疗前后甲状腺功能、甲状腺抗体、中医证候积分以及各组受试者治疗前外周淋巴细胞因子水平。结果治疗组临床疗效总有效率为85.00%

对照组为62.50%

治疗组疗效优于对照组（P<0.05）。治疗组治疗前后甲状腺功能比较差异均无统计学意义（P>0.05）。治疗组治疗后甲状腺过氧化酶抗体、甲状腺球蛋白抗体均较治疗前明显下降（P<0.01）

促甲状腺受体抗体比较差异无统计学意义（P>0.05）。治疗组治疗后中医证候积分明显下降（P<0.01）

并且明显低于对照组治疗后（P<0.05）。治疗前两组患者外周淋巴细胞因子的表达均高于健康对照组（P<0.01）。结论疏肝清热方可以改善桥本甲状腺炎患者的抗体水平及临床症状

其作用机制可能与改善辅助性T细胞平衡偏移有关。

Abstract

Objective To observe the clinical effect of Shugan Qingre Fang（疏肝清热方） in the treatment of Hashimoto thyroiditis（ HT） and to explore the possible mechanism. Methods Eighty HT patients were randomized into the treatment group（ 40 cases） and the control group（ 40 cases）. Another healthy control group（ 20 cases） was established. The treatment group was given herb compound prescription granules of Shugan Qingre Fang

one dose daily. The control group was given 25μg of levothyroxine sodium tablets once daily. Both groups took medicine orally for 12 weeks. The healthy control group was not given any medicine. Thyroid function

thyroid antibody and scores of Chinese medicine syndromes in two patient groups were observed before and after treatment. Therapeutic effect was evaluated in two patient groups after treatment. Level of peripheral lymphocyte factor was tested in three groups before treatment. Results Total effective rate was 85. 00% in the treatment group

and 62. 50% in the control group

with a significant difference between the two groups（ P < 0. 05）. There was no significant difference in thyroid function in the treatment group before and after treatment（ P > 0. 05）. After treatment

levels of thyroid peroxidase antibody（ TPO-Ab） and thyroglobulin antibody（ Tg-Ab） decreased remarkably in the treatment group（ P < 0. 01）; but there was no significant difference in level of thyrotropin receptor antibody（ TR-Ab） in the treatment between before and after treatment（ P > 0. 05）. After treatment

scores of Chinese medicine syndromes decreased significantly in the treatment group（ P < 0. 01） and it was obviously lower than those in the control group after treatment（ P < 0. 05）.The expressions of CCR5% and CD30% of HT patients in both groups were higher than those in the healthy control group before treatment; while CCR5 / CD30 in both groups was lower than that in the healthy control group（ P <0. 01）. Conclusion Shugan Qingre Fang could improve antibody levels and clinical symptoms of HT patients.The mechanism might relate to improving balance shift of helper T cell.

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