Objective To observe the curative effects and possible mechanism of Huoxue Tongmai Tang combined with conventional western medicine therapy to prevent and control restenosis of patients after coronary artery stenting. Methods Sixty patients with acute coronary syndrome after successful coronary artery stenting were randomly divided into the treatment group and the control group

with 30 cases in each group. Both groups were given conventional therapy of western medicine

and the treatment group was also added with Huoxue Tongmai Tang

1 dose daily. Both groups were treated for six months. Before operation

just after operation and after medication for 6months that been given Chinese medicine

the changes in plasma levels of oxidized low-density lipoprotein（ ox-LDL）

high-sensitivity C-reactive protein（ hs-CRP） and blood lipids( including total cholesterol（ TC）

triglyceride（ TG）

low-density lipoprotein cholesterol（ LDL-C）

and high-density lipoprotein cholesterol（ HDL-C） ]

Chinese medical syndrome integral

and angina symptom integral of patients in two groups were observed

and the numbers of restenosis after operation were compared. Results Levels of hs-CRP

ox-LDL

TC

TG

and LDL-C

Chinese medical syndrome integral

and angina symptom integral reduced obviously

but HDL-C increased obviously in the two groups just after operation comparing with before the operation（ P < 0. 05）. After taking Chinese medicine for 6 months

level of hs-CRP was lower

but level of ox-LDL

angina symptom integral

and Chinese medical syndrome integral were higher in the treatment group than that before operation. Levels of hs-CRP

TC

TG

and LDL-C

angina symptom integral

and Chinese medical syndrome integral were higher

but HDL-C was lower in the control group than those just after operation（ all P < 0. 05）. After taking Chinese medicine for 6 months

levels of hs-CRP

ox-LDL

TC

TG

and LDL-C were lower

but HDL-C was higher in the treatment group than those just after operation（ P <0. 05）

and angina symptom integral and Chinese medical syndrome integral in the two groups were lower than those before operation（ P < 0. 05）. After taking Chinese medicine for 6 months

levels of hs-CRP

ox-LDL

TC

TG

and LDL-C

angina symptom integral

and Chinese medical syndrome integral in the treatment group were lower

but HDL-C was higher than those in the control group at the same timepoint（ P < 0. 05）. After operation there were one ordinary stent

non drug-eluting stent

and one restenosis in the treatment group

which were much lower than 5 ordinary stents

2 drug-eluting stents

and 7 restenosis in the control group（ P < 0. 05）. Conclusion Huoxue Tongmai Tang combined with western medical conventional therapy may reduce restenosis after coronary artery stenting

and obviously relieve clinical symptoms of postoperative patients. Its mechanism may be related to improve blood lipid and reduce plasma levels of ox-LDL and hs-CRP.