Objective To evaluate clinical efficacy of Yiwei Huacai Fang for chronic atrophic gastritis with stomach-Yin deficiency. Methods Multi-center clinical study design methods including randomized block

doubleblind and double-dummy and parallel control were adopt. Forty-four cases of chronic atrophic gastritis with stomachYin deficiency syndrome were randomly divided into an experimental group（ 20 cases） and a control group（ 24 cases）. The experimental group was given boil-free granule with Yiwei Huacai Fang

one dose daily

and simulative vatacoenayme tablets

1 g each time

three times a day. The control group was given vatacoenayme 0. 8 g each time

three times a day

and boil-free granule with simulative Yiwei Huacai Fang

one dose daily. Both groups were treated for 12 weeks. Scores of Chinese medicine syndrome in two groups were observed before treatment

1

2

4

8

and 12 weeks after starting treatment

and 4 weeks after stopping medication. Classification of gastroscope and pathological mucosa atrophy were observed in two groups before and after treatment

and clinical efficacy was evaluated. Results The total effective rate in the experimental group was 85. 0%

which was significantly better than 66. 7% in the control group（ P < 0. 05）. Eight and 12 weeks after starting treatment and 4 weeks after stopping medication

the primary symptom score and the total score of Chinese medicine syndrome score were much lower in the experimental group than those in the control group（ P < 0. 01）. After treatment

classification of gastroscope and pathological mucosa atrophy showed improving trend in both two groups

but there was no significant differences in changes of classification between before and after treatment in both groups（ P > 0. 05）. Conclusion There is definite curative effect of Yiwei Huacai Fang in the treatment of chronic atrophic gastritis with stomach-Yin deficiency syndrome

and it may significantly improve patients’ clinical symptoms.