Clinical Observation on Xiaoyan Decoction（ 消岩汤） Combined with Elemene Injection Treating 41 Cases of Cancer Cachexia

ZHANG Yunchao; JIA Yingjie; ZHU Jinli; HUANG Minna; CHEN Jun; SUN Yiyu; YU Jianchun; DUAN Haobo; LIU Honggen

doi:10.13288/j.11-2166/r.2016.07.010

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Clinical Observation on Xiaoyan Decoction（消岩汤） Combined with Elemene Injection Treating 41 Cases of Cancer Cachexia

更新时间：2021-11-17

- Clinical Observation on Xiaoyan Decoction（消岩汤） Combined with Elemene Injection Treating 41 Cases of Cancer Cachexia
- Journal of Traditional Chinese Medicine Vol. 57, Issue 7, Pages: 574-578(2016)
- 作者机构：
  
  天津中医药大学第一附属医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2016.07.010
  CLC： R730.5
- Published：2016
- 稿件说明：
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[1]张蕴超,贾英杰,朱津丽,黄敏娜,陈军,孙一予,于建春,段浩博,刘宏根.消岩汤联合榄香烯注射液治疗癌症恶病质41例临床观察[J].中医杂志,2016,57(07):574-578.

ZHANG Yunchao, JIA Yingjie, ZHU Jinli, et al. Clinical Observation on Xiaoyan Decoction（消岩汤） Combined with Elemene Injection Treating 41 Cases of Cancer Cachexia[J]. Journal of Traditional Chinese Medicine2016, 57(7): 574-578.
[1]张蕴超,贾英杰,朱津丽,黄敏娜,陈军,孙一予,于建春,段浩博,刘宏根.消岩汤联合榄香烯注射液治疗癌症恶病质41例临床观察[J].中医杂志,2016,57(07):574-578. DOI： 10.13288/j.11-2166/r.2016.07.010.

ZHANG Yunchao, JIA Yingjie, ZHU Jinli, et al. Clinical Observation on Xiaoyan Decoction（消岩汤） Combined with Elemene Injection Treating 41 Cases of Cancer Cachexia[J]. Journal of Traditional Chinese Medicine2016, 57(7): 574-578. DOI： 10.13288/j.11-2166/r.2016.07.010.

摘要

目的观察消岩汤联合榄香烯注射液治疗癌症恶病质的临床疗效。方法将121例癌症恶病质患者随机分为对照组40例、榄香烯组40例和联合组41例。各组均予18AA-Ⅱ复方氨基酸注射液250 ml静脉滴注

每日1次;对照组加用甲地孕酮分散片口服

每次160 mg

每天1次;榄香烯组加用榄香烯注射液0.2 g静脉滴注

每日1次;联合组加用中药消岩汤口服联合榄香烯注射液0.2 g静脉滴注

每日1次。各组疗程均为2个月

分别观察治疗前后患者进食量、体质量、卡氏功能状态评分判定疗效

测定上臂中部周径及相关生化指标（血红蛋白、白蛋白、瘦素、肿瘤坏死因子α、白细胞介素6）及免疫功能指标（T淋巴细胞亚群及NK）。结果对照组、榄香烯组和联合组进食量疗效总有效率分别为70.0%、72.5%、85.4%

体质量疗效总有效率分别为60.0%、72.5%

80.5%

卡氏功能状态评分疗效总有效率分别为65.0%、67.5%

82.9%

联合组均优于对照组及榄香烯组（P<0.05）。治疗后榄香烯组和联合组均较对照组上臂中部周径明显提高（P<0.05）。治疗后联合组血红蛋白、白蛋白、瘦素、肿瘤坏死因子α、白细胞介素6、CD3+、CD4+、CD4+/CD8+及NK水平与本组治疗前及对照组治疗后比较均明显升高

CD8+水平降低（P<0.05）。治疗后与榄香烯组比较

联合组白蛋白、CD4+/CD8+显著升高

CD8+显著降低（P<0.05）。结论消岩汤联合榄香烯注射液可通过减少炎性细胞因子产生

提高免疫功能

改善癌症恶病质肌肉蛋白质降解

促进患者骨骼肌肌肉增长

从而改善癌症恶病质状态。

Abstract

Objective To observe the clinical effect of Xiaoyan Decoction（消岩汤） combined with elemene injection on cancer cachexia. Methods One hundred and twenty-one patients with cancer cachexia were randomized into control group（ 40 cases）

elemene group（ 40 cases） and combination group（ 41 cases）. All groups were given 18AA-Ⅱcompound amino acid injection 250 ml intravenous drip

once every day. The control group was added megestrol acetate dispersible tablets orally

160 mg each time

once every day. The elemene group was added elemene injection 0. 2 g intravenous drip

once every day. The combination group was added Xiaoyan Decoction orally and elemene injection 0. 2 g intravenous drip

once every day. All groups were treated for 2 months. Examined patients’ intake

body mass

Karnofsky Performance Status（ KPS） scores. Detected the girth of middle upper arm and related biochemical indexes

such as hemoglobin

albumin

leptin

tumor necrosis factor-α

interleukin 6 and immune function indexes including T lymphocyte subsets and natural killer cells（ NK）. Results The total effective rate of intake in the control group

the elemene group and the combination group was respectively 70. 0%

72. 5% and85. 4%; the total effective rate of body mass was 60. 0%

72. 5% and 80. 5% respectively; the total effective rate of KPS scores were 65. 0%

67. 5% and 82. 9%. The combination group was superior to the control group and the elemene group（ P

0. 05）. After treatment

compared with the control group

the girth of middle upper arm in the elemene group and the combination group increased significantly（ P

0. 05）. After treatment

hemoglobin

albumin

leptin

tumor necrosis factor-α

interleukin 6

CD3

CD4

/ CD8

and NK in the combination group increased significantly compared with before treatment

and with the control group after treatment. CD8

decreased（ P

0. 05）. After treatment

compared with the elemene group

albumin and CD4

/ CD8

in the combination group increased significantly. CD8

decreased significantly（ P

0. 05）. Conclusion Xiaoyan Decoction combined with elemene injection might enhance immune function

improve muscle protein degradation of cancer cachexia and promote muscle growth of patients’ skeletal muscles by reducing inflammatory cytokines to improve cancer cachexia status.

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Related Institution

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