Impact of Xiaoyan Decoction （消岩汤） on Muscle Protein Degradation in Lung Cancer Cachexia Mice

ZHANG Yunchao; JIA Yingjie; ZHU Jinli; ZHAO Linlin; LIU Honggen; KONG Fanming; DUAN Haobo; CHEN Jun; SUN Yiyu; YU Jianchun

doi:10.13288/j.11-2166/r.2016.09.015

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Impact of Xiaoyan Decoction （消岩汤） on Muscle Protein Degradation in Lung Cancer Cachexia Mice

更新时间：2021-11-17

- Impact of Xiaoyan Decoction （消岩汤） on Muscle Protein Degradation in Lung Cancer Cachexia Mice
- Journal of Traditional Chinese Medicine Vol. 57, Issue 9, Pages: 775-778(2016)
- 作者机构：
  
  1. 天津中医药大学第一附属医院
  2. 天津中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2016.09.015
  CLC： R285.5
- Published：2016
- 稿件说明：
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[1]张蕴超,贾英杰,朱津丽,赵林林,刘宏根,孔凡铭,段浩博,陈军,孙一予,于建春.消岩汤对肺癌恶病质小鼠肌肉蛋白质降解的影响[J].中医杂志,2016,57(09):775-778.

ZHANG Yunchao, JIA Yingjie, ZHU Jinli, et al. Impact of Xiaoyan Decoction （消岩汤） on Muscle Protein Degradation in Lung Cancer Cachexia Mice[J]. Journal of Traditional Chinese Medicine2016, 57(9): 775-778.
[1]张蕴超,贾英杰,朱津丽,赵林林,刘宏根,孔凡铭,段浩博,陈军,孙一予,于建春.消岩汤对肺癌恶病质小鼠肌肉蛋白质降解的影响[J].中医杂志,2016,57(09):775-778. DOI： 10.13288/j.11-2166/r.2016.09.015.

ZHANG Yunchao, JIA Yingjie, ZHU Jinli, et al. Impact of Xiaoyan Decoction （消岩汤） on Muscle Protein Degradation in Lung Cancer Cachexia Mice[J]. Journal of Traditional Chinese Medicine2016, 57(9): 775-778. DOI： 10.13288/j.11-2166/r.2016.09.015.

摘要

目的探讨消岩汤治疗肺癌恶病质的可能作用机制。方法将40只小鼠随机分为健康组、模型组、消岩汤组、醋酸甲地孕酮组

每组10只。除健康组外

其余各组通过接种肿瘤细胞建立肺癌恶病质模型。造模成功后模型组小鼠每日灌服生理盐水1 ml

消岩汤组每日灌服消岩汤0.42 g

醋酸甲地孕酮组每日灌服醋酸甲地孕酮3.75 mg/d

均给药14天。测定腓肠肌重量

血清肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）含量及肌肉萎缩盒F基因（MAFbx）和肌肉环状指基因1（MURF-1）m RNA表达。结果与健康组比较

模型组腓肠肌重量下降

模型组和醋酸甲地孕酮组TNF-α、IL-6水平及MAFbx、MURF-1m RNA表达均明显上升（P<0.01）;与模型组比较

消岩汤组腓肠肌重量明显增加

血清TNF-α、IL-6水平及MAFbx、MURF-1 m RNA表达均明显下降（P<0.05或P<0.01）

醋酸甲地孕酮组TNF-α、IL-6水平均明显下降（P<0.05）;醋酸甲地孕酮组腓肠肌重量明显低于消岩汤组（P<0.01）

血清TNF-α、IL-6水平及MAFbx、MURF-1 m RNA表达明显高于消岩汤组（P<0.05或P<0.01）。结论消岩汤可能通过减少炎症细胞因子产生

抑制MAFbx和MURF-1基因表达

改善肺癌恶病质肌肉蛋白质降解

从而改善肺癌恶病质状态。

Abstract

Objective To explore the possible mechanism of Xiaoyan Decoction（消岩汤） treating lung cancer cachexia. Methods Forty mice were randomized into healthy group

model group

Xiaoyan Decoction group and megestrol acetate group

10 mice in each group. Other groups except the healthy group were established lung cancer cachexia models by cancer cells inoculation. After successful modeling

mice in the model group were given normal saline 1ml by gavage every day. The Xiaoyan Decoction group was given Xiaoyan Decoction 0. 42 g by gavage every day. The megestrol acetate group was given megestrol acetate suspension 3. 75 mg / d by gavage every day

all group treated for 14 days. The weight of gastrocnemius was measured. The content of serum tumor necrosis factorα（ TNF-α） and interleukin 6（ IL-6）

expressions of muscular atrophy box F gene（ MAFbx） and muscle ring finger 1（ MURF-1） m RNA were detected. Results Compared with the healthy group

the weight of gastrocnemius in the model group decreased. The content of TNF-α and IL-6

as well as the expressions of MAFbx and MURF-1 m RNA in the model group and the megestrol acetate group increased（ P < 0. 01）. Compared with the model group

the weight of gastrocnemius in the Xiaoyan Decoction group increased. The content of serum TNF-α and IL-6

as well as the expressions of MAFbx m RNA and MURF-1 m RNA decreased（ P < 0. 05 or P < 0. 01）. The content of TNF-α and IL-6 in the megestrol acetate group decreased（ P < 0. 05）. The weight of gastrocnemius in the megestrol acetate group was much smaller than that in the Xiaoyan Decoction group（ P < 0. 01）; the level of serum TNF-α and IL-6

as well as the expressions of MAFbx and MURF-1 m RNA were higher than those in the Xiaoyan Decoction group（ P < 0. 05 or P < 0. 01）. Conclusion Xiaoyan Decoction may improve status of lung cancer cachexia through inhibiting the expressions of MAFbx and MURF-1 genes

improving muscle protein degradation and reducing inflammatory cytokines production.

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