Impact of Huotan Huayu Decoction （豁痰化瘀方） Combined with Western Medicine on Serum Homocysteine Level in Patients with Coronary Heart Disease without Percutaneous Coronary Intervention Therapy

WANG Yuxiao

doi:10.13288/j.11-2166/r.2016.10.011

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Impact of Huotan Huayu Decoction （豁痰化瘀方） Combined with Western Medicine on Serum Homocysteine Level in Patients with Coronary Heart Disease without Percutaneous Coronary Intervention Therapy

更新时间：2021-11-17

- Impact of Huotan Huayu Decoction （豁痰化瘀方） Combined with Western Medicine on Serum Homocysteine Level in Patients with Coronary Heart Disease without Percutaneous Coronary Intervention Therapy
- Journal of Traditional Chinese Medicine Vol. 57, Issue 10, Pages: 852-855(2016)
- 作者机构：
  
  平顶山市第二人民医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2016.10.011
  CLC： R541.4
- Published：2016
- 稿件说明：
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[1]王玉晓.豁痰化瘀方联合西药对冠心病非经皮冠状动脉介入治疗患者血浆同型半胱氨酸水平的影响[J].中医杂志,2016,57(10):852-855.

WANG Yuxiao. Impact of Huotan Huayu Decoction （豁痰化瘀方） Combined with Western Medicine on Serum Homocysteine Level in Patients with Coronary Heart Disease without Percutaneous Coronary Intervention Therapy[J]. Journal of Traditional Chinese Medicine2016, 57(10): 852-855.
[1]王玉晓.豁痰化瘀方联合西药对冠心病非经皮冠状动脉介入治疗患者血浆同型半胱氨酸水平的影响[J].中医杂志,2016,57(10):852-855. DOI： 10.13288/j.11-2166/r.2016.10.011.

WANG Yuxiao. Impact of Huotan Huayu Decoction （豁痰化瘀方） Combined with Western Medicine on Serum Homocysteine Level in Patients with Coronary Heart Disease without Percutaneous Coronary Intervention Therapy[J]. Journal of Traditional Chinese Medicine2016, 57(10): 852-855. DOI： 10.13288/j.11-2166/r.2016.10.011.

摘要

目的观察豁痰化瘀方治疗冠心病非经皮冠状动脉介入治疗术患者的临床疗效及可能作用机制。方法 80例患者随机分为对照组（36例）和治疗组（44例）

对照组采用冠心病治疗指南规范治疗

治疗组在对照组基础上加用豁痰化瘀方

每日1剂

两组均治疗30天。观察两组心绞痛疗效及心电图疗效

治疗前后采用西雅图量表评价患者生活质量

检测血浆同型半胱氨酸水平的变化。结果治疗组心绞痛疗效总有效率为88.6%

对照组为72.2%;治疗组心电图疗效总有效率为90.9%

对照组为63.9%;治疗组患者心绞痛疗效及心电图疗效均优于对照组（P<0.05）。治疗组治疗后西雅图量表评分中心绞痛稳定状态、心绞痛发作情况及治疗满意程度评分均较本组治疗前明显升高（P<0.05或P<0.01）;对照组治疗后心绞痛稳定状态、心绞痛发作情况评分亦较本组治疗前升高（P<0.01）;两组治疗后组间比较

治疗组心绞痛发作情况评分高于对照组（P<0.05）。两组治疗后血浆同型半胱氨酸均较本组治疗前降低（P<0.01）

治疗组较对照组降低更显著（P<0.05）。结论豁痰化瘀方联合西药治疗冠心病非经皮冠状动脉介入治疗患者可明显提高临床疗效

改善生活质量

其作用可能与降低血浆同型半胱氨酸水平有关。

Abstract

Objective To observe the clinical effect and possible mechanism of Huotan Huayu Decoction（豁痰化瘀方） in treating patients with coronary heart disease without percutaneous coronary intervention therapy. Methods Eighty patients were randomized into a control group（ 36 cases） and a treatment group（ 44 cases）. The control group was given standard treatment

following guidelines for treatment of coronary heart disease. The treatment group was given standard treatment and Huotan Huayu Decoction

one dose every day. Both groups were treated for 30 days. The effect on angina and electrocardiogram in both groups were examined. Quality of life was evaluated with Seattle Angina Questionnaire before and after treatment. Changes of serum homocysteine level were detected. Results For the treatment of angina

the total effective rate was 88. 6% in the treatment group

and 72. 2% in the control group. For the effect on electrocardiogram

the total effective rate was 90. 9% in the treatment group

and 63. 9% in the control group. The effect on angina and electrocardiogram in the treatment group was superior to that in the control group（ P <0. 05）. Results from Seattle Angina Questionnaire evaluation showed that

after treatment

scores of angina stable state

angina attack situation and satisfaction degree of treatment in the treatment group were higher than those before treatment（ P < 0. 05 or P < 0. 01）. After treatment

the scores of angina stable state and angina attack situation in the control group were higher than those before treatment（ P < 0. 01）. After treatment

the score of angina attack situation in the treatment group was higher than that in the control group（ P < 0. 05）. After treatment

serum level of homocysteine in both groups decreased（ P < 0. 01）

especially in the treatment group（ P < 0. 05）. Conclusion Huotan Huayu Decoction combined with Western medicine for patients with coronary heart disease without percutaneous coronary intervention therapy might improve the clinical effect and quality of life. The effect might relate to reduction of the serum level of homocysteine.

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