Energy Metabolism Disorder and Spleen Deficiency Being the Key Pathogenesis of Depression

DING Xia; JING Linlin; WEN Ge; SUN Xuegang

doi:10.13288/j.11-2166/r.2016.11.007

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Energy Metabolism Disorder and Spleen Deficiency Being the Key Pathogenesis of Depression

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- Energy Metabolism Disorder and Spleen Deficiency Being the Key Pathogenesis of Depression
- Journal of Traditional Chinese Medicine Vol. 57, Issue 11, Pages: 924-926(2016)
- 作者机构：
  
  1. 北京中医药大学
  2. 南方医科大学中西医结合医院
  3. 南方医科大学南方医院
  4. 南方医科大学中医药学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2016.11.007
  CLC： R277.7
- Published：2016
- 稿件说明：
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[1]丁霞,靖林林,文戈,孙学刚.论脾虚及能量代谢障碍是抑郁症发病的关键病机[J].中医杂志,2016,57(11):924-926.

DING Xia, JING Linlin, WEN Ge, et al. Energy Metabolism Disorder and Spleen Deficiency Being the Key Pathogenesis of Depression[J]. Journal of Traditional Chinese Medicine2016, 57(11): 924-926.
[1]丁霞,靖林林,文戈,孙学刚.论脾虚及能量代谢障碍是抑郁症发病的关键病机[J].中医杂志,2016,57(11):924-926. DOI： 10.13288/j.11-2166/r.2016.11.007.

DING Xia, JING Linlin, WEN Ge, et al. Energy Metabolism Disorder and Spleen Deficiency Being the Key Pathogenesis of Depression[J]. Journal of Traditional Chinese Medicine2016, 57(11): 924-926. DOI： 10.13288/j.11-2166/r.2016.11.007.

摘要

能量代谢障碍是抑郁症病因之一

而脾虚不能升清致神失所养则是能量代谢失常诱发抑郁症的中医病机。线粒体可能是能量代谢失常致抑郁发生的超微结构基础

应激状态下内质网和线粒体的功能障碍可导致三磷酸腺苷（ATP）降低和神经元凋亡

而自噬是抑郁症发病的重要调控机制。

Abstract

Energy metabolism is one of the causes of depression

and mind lacking of nourishment due to spleen deficiency unable to send nutrients upward is the Chinese medicine pathogenesis of depression induced by energy metabolism disorder. Mitochondria may be the ultrastructural basis of depression induced by energy metabolism disorder.In stress state

the endoplasmic reticulum and mitochondria dysfunction may lead to a decrease in adenosine triphosphate（ ATP） and neuronal apoptosis. Autophagy is an important regulation and control mechanism of depression.

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