Systematic Review and Meta Analysis of Efficacy of Acupuncture in the Treatment of Premature Ovarian Failure

LUO Xi; LI Xi; CHENG Jie; HUA Qixin; XIE Zhengyun; YANG Pengyan; XIA Youbing

doi:10.13288/j.11-2166/r.2016.12.010

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Systematic Review and Meta Analysis of Efficacy of Acupuncture in the Treatment of Premature Ovarian Failure

更新时间：2021-11-17

- Systematic Review and Meta Analysis of Efficacy of Acupuncture in the Treatment of Premature Ovarian Failure
- Journal of Traditional Chinese Medicine Vol. 57, Issue 12, Pages: 1027-1032(2016)
- 作者机构：
  
  1. 南京医科大学
  2. 南京中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2016.12.010
  CLC： R246.3
- Published：2016
- 稿件说明：
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[1]罗玺,李茜,程洁,华启新,谢政芸,杨鹏燕,夏有兵.针灸治疗卵巢早衰有效性的系统综述与Meta分析[J].中医杂志,2016,57(12):1027-1032.

LUO Xi, LI Xi, CHENG Jie, et al. Systematic Review and Meta Analysis of Efficacy of Acupuncture in the Treatment of Premature Ovarian Failure[J]. Journal of Traditional Chinese Medicine2016, 57(12): 1027-1032.
[1]罗玺,李茜,程洁,华启新,谢政芸,杨鹏燕,夏有兵.针灸治疗卵巢早衰有效性的系统综述与Meta分析[J].中医杂志,2016,57(12):1027-1032. DOI： 10.13288/j.11-2166/r.2016.12.010.

LUO Xi, LI Xi, CHENG Jie, et al. Systematic Review and Meta Analysis of Efficacy of Acupuncture in the Treatment of Premature Ovarian Failure[J]. Journal of Traditional Chinese Medicine2016, 57(12): 1027-1032. DOI： 10.13288/j.11-2166/r.2016.12.010.

摘要

目的系统评价针灸治疗卵巢早衰的有效性。方法计算机检索Pub Med、Medline、EMbase、中国期刊全文数据库、维普数据库、中国生物医学文献数据库、万方数据库

检索时间从各数据库建库至2015年7月31日

收集针灸治疗卵巢早衰的随机对照临床研究文献。对纳入的文献进行偏倚风险和质量评估

并对针灸治疗卵巢早衰的月经恢复总有效率、血清促卵泡生成激素（FSH）、黄体生成素（LH）及雌二醇（E2）的改善进行Meta分析。结果纳入12个随机对照试验

Meta分析结果显示

针灸治疗后月经恢复总有效率[RR=1.26

95%CI（1.16

1.36）

P<0.00001]和血清FSH的改善[WMD=-6.27

95%CI（-10.56

-1.98）

P=0.004]优于西药对照组;针灸结合西药治疗后月经恢复总有效率[RR=1.25

95%CI（1.11

1.40）

P=0.0002]及血清FSH的改善[WMD=-11.71

95%CI（-20.81

-2.60）

P=0.01]优于西药对照组。针灸与针灸结合西药治疗结束6个月后

患者月经恢复总有效率明显高于西药对照组[RR=2.37

95%CI（1.77

3.18）

P<0.001;RR=1.58

95%CI（1.17

2.13）

P=0.003]。针灸治疗结束1个月后血清FSH、LH的改善高于西药对照组[WMD=-13.25

95%CI（-17.89

-8.60）

P<0.0001;WMD=-7.57

95%CI（-12.04

-3.09）

P=0.0009]。结论针灸治疗卵巢早衰对患者月经恢复和改善患者血清FSH水平有效

短期内疗效能维持。

Abstract

Objective To evaluate the efficacy of acupuncture in the treatment of premature ovarian failure（ POF） systematically. Methods Literature published from the time databases were built until July 31 st

2015 was searched from Pub Med / MEDLINE

EMbase

Journal Full-Text Database of China National Knowledge Infrastructure

VIP Data

Chinese Biological Medical Literature Database on disc

and Wan Fang Data. Papers of randomized controlledtrials on acupuncture treatment of POF were collected. Bias of risk and quality of included papers were evaluated. Meta analysis were carried out on the total effective rate of menstruation recovery and the improvement of serum levels of follicle-stimulating hormone（ FSH）

luteinizing hormone（ LH） and estradiol（ E2） in patients with POF after acupuncture treatment. Results Twelve randomized controlled trials were included. Meta analysis showed that after acupuncture treatment

the total effective rate of menstruation recovery [RR = 1. 26

95% CI（ 1. 16

1. 36）

P < 0. 00001] and the improvement of serum FSH [WMD =- 6. 27

95% CI（- 10. 56

- 1. 98）

P = 0. 004]were superior to those in the western medicine control group. After the treatment of acupuncture combined with western medicine

the total effective rate of menstruation recovery [RR = 1. 25

95% CI（ 1. 11

1. 40）

P = 0. 0002]and the improvement of serum level of FSH [WMD =- 11. 71

95% CI（- 20. 81

- 2. 60）

P = 0. 01] were superior to those in the western medicine control group. Six months after the treatment of acupuncture and acupuncture combined with western medicine

patients’ total effective rate of menstruation recovery was much higher than that in the western medicine control group [RR = 2. 37

95% CI（ 1. 77

3. 18）

P < 0. 001; RR = 1. 58

95% CI（ 1. 17

2. 13）

P = 0. 003]. One month after acupuncture treatment

the improvement of serum levels of FSH and LH were more obvious than that in the western medicine control group [WMD =- 13. 25

95% CI（- 17. 89

- 8. 60）

P <0. 0001; WMD =- 7. 57

95% CI（- 12. 04

- 3. 09）

P = 0. 0009]. Conclusion Acupuncture treatment of POF is effective on patients’ menstruation recovery and the improvement of patients’ serum level of FSH. The efficacy could be maintained in a short time.

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