Objective To analyze the onset characteristics and their differences in patients confirmed with dengue at different time to provide basis for clinical treatment. Methods Clinical data of patients from Liwan District

Guangzhou

who were confirmed with dengue in the year 2013 and 2014

were collected. Factors including age

gender

time of onset

and clinical feature of patients in different year were compared. Results Totally 257 cases in 2013 and 465 cases in 2014 were collected. Among patients in 2013

there were 148 cases of male and 109 cases of female

with age from 10 to 84 years old; among patients in 2014

there were 227 cases of male and 238 cases of female

with age from 12 to 92 years old. Compared with those in 2014

patients’ age in 2013 was lower

and the proportion of male patients in 2013 was higher

and there were statistically significant differences（ P < 0. 05）. The peak periods of dengue were both in October in 2013 and 2014

while the secondary maximum of morbidity was in November in 2013

and September in 2014. There was significant difference in distribution of disease time between the two years（ P < 0. 05）. The proportion of patients presenting with poor appetite

rash

heavy body and weak

muscle pain and bone pain in 2014 was higher than that in 2013（ P < 0. 05）. Conclusion There are different population characteristics

time characteristics and clinical characteristics in dengue onset. It should be combined with climate

phenology and disease differentiations to conduct treatment based on symptom differentiation.