Objective To explore the possible mechanism of Huoxue Yiqi Fang（ 活血益气方） in promoting angiogenesis and its compatibility law. Methods Sprague Dawley Rats（ n = 30） were randomly divided into sham operation group

model group

Huoxue Yiyi Fang Group

Yiqi Fang Group

and Huoxue Fang Group

with 6 rats in each group. Myocardial infarction models were established in all groups except sham operation group. Twenty-four hours after modeling

Yiqi Huoxue Fang group

Yiqi Fang group and Huoxue Fang group were given 3. 2 g / ml

2. 4 g / ml and 0. 8 g / ml of corresponding Chinese medicines（ Chinese medicine solution 0. 5 ml /100 g） respectively

while model group and sham operation group were given normal saline

once daily. Four weeks later

myocardial tissue in the infarct zone of rats was taken out from each group. The expression of miR-126 and vascular endothelial growth factor（ VEGF） mRNA were detected by real-time fluorescence quantitative PCR. Results The expression of miR-126 in model group rats（ myocardial infarction border area group） was lower than that in sham operation group（ P < 0. 01）; The expression of miR-126 in Yiqi Huoxue Fang group

Yiqi Fang group and Huoxue Fang group was lower than that in model group

the expression of VEGF mRNA in Huoxue Yiqi Fang group and Huoxue Fang group were higher than that in model group（ P < 0. 05 or P < 0. 01）; The regulation of miR-126 and VEGF mRNA in Huoxue Yiqi Fang group was better than that in Yiqi Fang group（ P < 0. 05 or P < 0. 01）. Conclusion The mechanism of Huoxue Yiqi Fang promoting angiogenesis may be related to the up-regulation of VEGF and down-regulation of its upstream regulatory factor miR-126

and promoting blood circulation drugs and supplementing Qi drugs have a synergistic effect.