Objective To study the effects of Jiashen Fang（ 加参方） on the cardiac function of rats with myocardial infarction and to explore the possible mechanism. Methods Anterior descending branch of left coronary artery of rats were ligatured to establish the rat models of acute myocardial infarction. Twenty-four hours after the operation

the survival rats were randomly divided into a control group（ 19）

a model group（ 30）

a low dose of Jiashen Fang group（ 31）

a high dose of Jiashen Fang group（ 30）

and a losartan group（ 30）. The low and high dose of Jiashen Fang groups were given extractum of Jiashen Fang with 3 g /（ kg·d） and 6 g /（ kg·d） of pure dose

respectively. The losartan group was given 10 mg /（ kg·d） of losartan tablets. The control group and the model group were given the equivalent distilled water. Each group was given medication or water by gavage for 4 weeks. One week and4 weeks after treatment

cardiac function was evaluated with ultrasonic testing

and levels of monocyte-macrophage and expression levels of vascular cell adhesion molecule-1（ VCAM-1） in danger area of myocardial tissue ischemia were tested

respectively. Results Compared with the control group at the same time point

cardiac function of rats decreased

and level of monocyte-macrophage and protein expression of VCAM-1 in myocardial tissue increased significantly in the model group（ P < 0. 05）; Compared with the model group at the same time point

cardiac function of rats improved significantly

and level of monocyte-macrophage and expression of VCAM-1 in the myocardial tissue decreased in the losartan group and the high dose of Jiashen Fang group（ P < 0. 05）. Conclusion Jiashen Fang may inhibit infiltration of monocyte-macrophage and protein expression of VCAM-1 in myocardial tissue of rats

improve the ventricular remodeling and improve cardiac function.