Objective To explore possible functional mechanism of Shuji Decoction（ 舒肌汤） in treating Parkinson disease muscle rigidity. Methods Using encephalic injection of Lactacystin to induce 24 Parkinson disease rigidity model rats in total. Divided them into the model group and the Chinese medicine high

middle and low dose groups randomly

with 6 in each group. Set 6 rats in the sham-operation group in addition（ injected with saline encephalicly）.The sham-operation group and the model group were both perfused with saline 20 g /（ kg · d）. Shuji Decoction was concentrated to 2. 0 g / ml. The Chinese medicine high

middle and low dose groups were respectively gavaged with Shuji Decoction 40

20 and 10 g /（ kg·d）

once per day

for 30 days. Examined content of dopamine（ DA）

homvanillic acid hva（ HVA） and dihydroxyphenylaceticacid（ DOPAC） in corpus striatum. Observed changes of ultrastructure at neuromuscular junction of nervus phrenicus under electron microscopy. Results Compared with the sham-operation group

the content of DA

HVA and DOPAC in rats of the model group remarkably decreased

with value of DA / DOPAC and DA / HVA decreased（ P < 0. 05 or P < 0. 01）; Compared with the model group

the content of DA

HVA

DOPAC

value of DA / DOPAC and DA / HVA of corpus striatum of mice in the Chinese medicine high

middle and low dose groups all remarkably increased（ P < 0. 05 or P < 0. 01）; Compared with the Chinese medicine middle dose group

content of COPAC

and value of DA / DOPAC

DA / HVA of the Chinese medicine high dose group decreased

and content of DOPAC of the Chinese medicine low dose group also decreased（ P < 0. 05）. Under electron microscopy

there existed changes of ultrastructure like muscular fiber concentrating and being arranged in disorder at neuromuscular junction

vesicles and mitochondria of presynaptic membrane increasing

postsynaptic membrane folding remarkably and acetylcholine receptors increaing. The above changes were improved in each dose of the Chinese medicine groups to different degree. Conclusion Shuji Decoction can release muscle rigidity in Parkinson by promoting secretion of DA

at the same time decreasing the release of acetyl choline at neuromuscular junction

and regulating central and peripheral nerve excitation.