Possibility and Prospect of Application of Association Study on Genomewide and Phenome-wide in Chinese Medicine Researches

ZHOU Xin; XUE Wenda; WU Haoxin; CHEN Gang

doi:10.13288/j.11-2166/r.2016.14.006

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Possibility and Prospect of Application of Association Study on Genomewide and Phenome-wide in Chinese Medicine Researches

更新时间：2021-11-17

- Possibility and Prospect of Application of Association Study on Genomewide and Phenome-wide in Chinese Medicine Researches
- Journal of Traditional Chinese Medicine Vol. 57, Issue 14, Pages: 1191-1194(2016)
- 作者机构：
  
  南京中医药大学转化系统生物学与神经科学研究中心
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2016.14.006
  CLC： R241
- Published：2016
- 稿件说明：
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[1]周欣,薛文达,吴颢昕,陈刚.全基因组及全表型组关联分析在中医药研究中应用的可能性与前景[J].中医杂志,2016,57(14):1191-1194.

ZHOU Xin, XUE Wenda, WU Haoxin, et al. Possibility and Prospect of Application of Association Study on Genomewide and Phenome-wide in Chinese Medicine Researches[J]. Journal of Traditional Chinese Medicine2016, 57(14): 1191-1194.
[1]周欣,薛文达,吴颢昕,陈刚.全基因组及全表型组关联分析在中医药研究中应用的可能性与前景[J].中医杂志,2016,57(14):1191-1194. DOI： 10.13288/j.11-2166/r.2016.14.006.

ZHOU Xin, XUE Wenda, WU Haoxin, et al. Possibility and Prospect of Application of Association Study on Genomewide and Phenome-wide in Chinese Medicine Researches[J]. Journal of Traditional Chinese Medicine2016, 57(14): 1191-1194. DOI： 10.13288/j.11-2166/r.2016.14.006.

摘要

中医辨证论治强调对患者进行个体化治疗

与现代医学所倡导的精准治疗有相通之处。中医体质与证候部分由先天禀赋决定

即遗传发挥了重要影响。全基因组关联分析可直接将基因变异性与疾病或生理性状相关联

全表型组关联分析可进一步获得特定的遗传变异位点所影响的不同表型。未来中医药研究中

可以通过全基因组关联分析和全表型组关联分析从全基因组的层面上来判别影响特定体质、证候与病证结合对证治疗的分子遗传基础

揭示中医辨证论治的现代生物学本质

为提高中医诊断与治疗的精准性与稳定性提供参考。

Abstract

Chinese medicine syndrome differentiation treatment emphasizes individualized treatment on patients

which is similar to precision treatment proposed by modern medicine. Chinese medicine constitution and syndrome is determined partly by natural endowment

which means that inheritance plays an important role. Genomewide association study could correlate gene mutation with disease or physiological characteristics directly. Phenomewide association study could further find out different phenotypes influenced by specific genetic variation site. In future Chinese medicine researches

molecular genetic basis

which is influenced by certain constitution

syndrome and disease-syndrome combination syndrome treatment

might be differentiated from genomewide aspect by genomewide association study and phenomewide association study. The essence of modern biology of Chinese medicine syndrome differentiation treatment might be revealed. This paper might provide reference for improving the precision and stability of Chinese medicine diagnosis and treatment.

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