Objective To investigate the application of the Clinical Guideline for Chinese Medicine Diagnosis and Treatment of Anxiety（ "anxiety guideline"for short） in the real world to get to know how it fit the circumstances of clinical reality

and provide reference for revising the guideline. Methods A prospective observation was conducted on 274 anxiety case records（ hospitalized patients or outpatients） with case investigation and analysis method.Data such as medical record number

gender

age and course of disease was collected. Information on diagnosis of Chinese medicine and western medicine

treatment based on syndrome differentiation

etc. was described and analyzed to see if it is accordance with the anxiety guideline. The conformity of anxiety guideline in clinical application was calculated. Cross-over analysis was conducted on the effect of conformity on clinical application. Results The conformity of disease diagnosis in Chinese medicine or in western medicine were 96. 71% and 97. 81%

repectively.The conformity of syndrome classification was 87. 59%. The conformity of treating principle was 88. 32%. The conformity of prescription name and herb composition was 86. 50%. Total rate of improvement

obvious effective rate

and cure effect added up to 99. 26% in clinical effect evaluation. The percentage of good safety and economy reached to 96. 35% and 91. 61%. After the anxiety guideline was applied in clinical

under the circumstances that syndrome classification

treating principle

prescription name and herb composition were all in accordance with the anxiety guideline

the percentage of patients with good clinical effect was 75. 18%. Application effect analysis showed that different clinical application conforming status could influence the application effect. Conclusion The anxiety guideline might conform to the actual situation of clinical treatment based on syndrome differentiation. The clinical application effect of the anxiety guideline seemed generally good. The conforming status of guideline for clinical diagnosis and treatment of anxiety in clinical could influence the clinical application effect. The guideline could be further revised for some cases without application conforming

considering the specific reasons in diagnosis

treatment based on syndrome differentiation

etc.

that caused the inconformity with the guideline.