Impact of Luofengning DecoctionⅡ（络风宁2号方） on Inflammatory Factors of Patients with Cardiorenal Syndrome

YANG Xueqing; WANG Xian

doi:10.13288/j.11-2166/r.2016.16.013

您当前的位置：

首页 >

文章列表页 >

Impact of Luofengning DecoctionⅡ（络风宁2号方） on Inflammatory Factors of Patients with Cardiorenal Syndrome

更新时间：2021-11-17

- Impact of Luofengning DecoctionⅡ（络风宁2号方） on Inflammatory Factors of Patients with Cardiorenal Syndrome
- Journal of Traditional Chinese Medicine Vol. 57, Issue 16, Pages: 1397-1401(2016)
- 作者机构：
  
  1. 北京中医医院顺义医院
  2. 北京中医药大学东直门医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2016.16.013
  CLC： R285.6
- Published：2016
- 稿件说明：
移动端阅览
[1]杨雪卿,王显.络风宁2号方对心肾综合征患者炎症因子的影响[J].中医杂志,2016,57(16):1397-1401.

YANG Xueqing, WANG Xian. Impact of Luofengning DecoctionⅡ（络风宁2号方） on Inflammatory Factors of Patients with Cardiorenal Syndrome[J]. Journal of Traditional Chinese Medicine2016, 57(16): 1397-1401.
[1]杨雪卿,王显.络风宁2号方对心肾综合征患者炎症因子的影响[J].中医杂志,2016,57(16):1397-1401. DOI： 10.13288/j.11-2166/r.2016.16.013.

YANG Xueqing, WANG Xian. Impact of Luofengning DecoctionⅡ（络风宁2号方） on Inflammatory Factors of Patients with Cardiorenal Syndrome[J]. Journal of Traditional Chinese Medicine2016, 57(16): 1397-1401. DOI： 10.13288/j.11-2166/r.2016.16.013.

摘要

目的探讨络风宁2号方治疗心肾综合征的可能作用机制。方法将120例心肾综合征患者随机分为全方组、去风药组、西药组各40例。西药组仅给予常规治疗;全方组在常规治疗的基础上口服络风宁2号免煎颗粒剂

每日1剂;去风药组在常规治疗的基础上口服去风药方免煎颗粒剂

每日1剂。各组均治疗2个月。比较各组治疗前后血浆超敏C反应蛋白（hs-CRP）、脂蛋白相关磷脂酶A2（Lp-PLA2）、心肌营养素1（CT-1）水平

并观察不良反应。结果与本组治疗前比较

全方组治疗后hs-CRP、LP-PLA2水平显著降低

CT-1水平显著升高（P<0.05或P<0.01）;西药组治疗后LP-PLA2、CT-1水平均显著升高（P<0.05或P<0.01）;去风药组CT-1水平显著升高（P<0.05）。治疗后全方组hs-CRP、LP-PLA2水平显著低于去风药组和西药组（P<0.05）

去风药组LP-PLA2水平显著低于西药组（P<0.05）。治疗后全方组CT-1水平显著高于去风药组

低于西药组（P<0.05）

去风药组显著低于西药组（P<0.05）。结论络风宁2号方在益气温阳、活血利水法基础上增加风药

增强了降低心肾综合征患者hs-CRP、LP-PLA2水平的效果

可能通过降低血浆中hs-CRP、LP-PLA2水平来发挥保护心肾功能的作用。

Abstract

Objective To explore the possible mechanism of Luofengning Decoction Ⅱ in the treatment of cardiorenal syndrome（ CRS）. Methods One hundred and twenty CRS patients were randomized into a full formula group

a without wind-expelling herbs group and a western medicine group（ 40 cases in each group）. The western medicine group was only given routine treatment. In addition to the routine treatment

the full formula group was also orally given single herbal concentrate-granules of Luofengning Decoction Ⅱ

one dose every day. In addition to the routine treatment

the without wind-expelling herbs group was also orally given the single herbal concentrate-granules of the prescription without wind-expelling herbs

one dose every day. All groups were treated for 2 months. The serum levels of high-sensitivity C-reactive protein（ hs-CRP）

lipoprotein-associated phospholipase A2（ Lp-PLA2） and cardiotrophin1（ CT-1） in all groups before and after treatment were compared. Side effect was examined. Results Compared with before treatment in the same group

levels of hs-CRP and LP-PLA2 decreased

but level of CT-1increased in the full formula group after treatment（ P < 0. 05 or P < 0. 01）. After treatment

levels of LP-PLA2 and CT-1 increased in the western medicine group（ P < 0. 05 or P < 0. 01）

and level of CT-1 increased in the without wind-expelling herbs group（ P < 0. 05）. After treatment

levels of hs-CRP and LP-PLA2 in the full formula group was much lower than those in the without wind-expelling herbs group and the western medicine group（ P < 0. 05）

and level of LP-PLA2 in the without wind-expelling herbs group was much lower than that in the western medicine group（ P < 0. 05）. After treatment

level of CT-1 in the full formula group was much higher than that in the without wind-expelling herbs group

but lower than that in the western medicine group（ P < 0. 05）

and level of CT-1 in the without wind-expelling herbs group was much lower than that in the western medicine group（ P < 0. 05）. Conclusion Luofengning Decoction Ⅱ is prescribed based on benefiting Qi

warming Yang

promoting blood circulation and diuresis method with wind-expelling herbs added in

which improved the effect of decreasing the levels of hs-CRP and LP-PLA2 in CRS patients. The possible mechanism might be decreasing the serum levels of hs-CRP and LP-PLA2 to protect the function of heart and kidney.

关键词

Keywords

references

查看原文

Views

150

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Yigan Fupi Prescription （抑肝扶脾方） on the AKT/mTOR Pathway in the Colon Tissue of Diarrhea-Type Irritable Bowel Syndrome Model Rats with Liver Stagnation and Spleen Deficiency Pattern

Effect of Acupuncture Combined with Bloodletting and Cupping on the Expression of Coagulation-Complement-Mast Cell Activation Axis-Related Factors in Patients with Chronic Spontaneous Urticaria：Randomize-controlled Study

Comparative Study on the Pharmacodynamics of Xiangzhu Fanggan Formula （香术防感方） by Sniffing and Nasal Drops for Prevention of Influenza A H1N1 Virus Infection in Mice

Effect of Qingyu Hejiang Decoction（清郁和降汤）on LPS/TLR4/NFκB Pathway and Esophageal Mucosal Barrier in Reflux Esophagitis Model Rats

Comparing the Mechanism of Action of Huangqi Guizhi Wuwu Decoction （黄芪桂枝五物汤） and Si Shen Decoction （四神煎） for Treatment of Rheumatoid Arthritis based on Network Pharmacology

Related Author

JIU Suting

LI Huiying

SUN Yueting

CUI Songxiang

XU Xintian

ZHENG Hao

LU Weimin

DU Yuzhu

Related Institution

Pukou District Hospital of Traditional Chinese Medicine

Qujing Hospital of Traditional Chinese Medicine

Affiliated Hospital of Nanjing University of Chinese Medicine

The Third Hospital of Hebei Medical University

The Second Hospital of Hebei Medical University

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰