Objective To summarize the herb compatibility rules in the treatment of Chronic Hepatitis B with different Chinese medicine syndrome types. Methods Related literature on Chinese medicine treatment of Chronic Hepatitis B were collected from China Integrated Knowledge Resources Database

VIP Data

Full text database of Wanfang academic journals and Chinese Biological Medical Literature Database on disc. Chronic Hepatitis B were divided into syndromes of liver depression and Qi stagnation

stagnation of liver Qi and spleen deficiency

accumulation and binding of damp-heat

static blood blocking collaterals

Yin deficiency of liver and kidney

and Yang deficiency of spleen and kidney. Herbs used in these syndromes in included literature were calculated. Herbs with use frequency in these syndromes more than 10% were made factor analysis and cluster analysis. Results Totally 243 papers were included. Syndrome of liver depression and Qi stagnation occurred 53 times

involving 108 herbs. There were 26 herbs with use frequency more than 10%

which could be clustered into 8 categories. Combination of commonly used herbs were Chaihu [Radix Bupleuri

柴胡]

Yinchen [Herba Artemisiae Scopariae

茵陈]

Banlan’ gen[Radix Isatidis

板蓝根]

Baihua Sheshecao [Herba Hedyotis

白花蛇舌草]

Xiangfu [Rhizoma Cyperi

香附]

Yujin [Radix Curcumae

郁金]

Zhiqiao [Fructus Aurantii

枳壳]

etc. Syndrome of accumulation and binding of damp-heat occurred 204 times

involving 174 herbs. There were 30 herbs with use frequency more than 10%

which could be clustered into 6 categories. Combination of commonly used herbs were Chaihu

Huangqin [Radix Scutellariae

黄芩]

Chishao [Radix Paeoniae Rubra

赤芍]

Baishao [Radix Paeoniae Alba

白芍]

Danggui [Radix Angelicae Sinensis

当归]

Danshen [Radix Salviae Miltiorrhizae

丹参]

Fuling [Poria

茯苓]

Yiyiren [Semen Coicis

薏苡仁]

Banlan’gen

Pugongying [Herba Taraxaci

蒲公英]

Yinchen

Dahuang [Radix et Rhizoma Rhei

大黄]

Zhizi[Fructus Gardeniae

栀子]

Baizhu [Rhizoma Atractylodis Macrocephalae

白术]

Huzhang [Rhizoma Polygoni Cuspidati

虎杖]

Yujin

Baihuasheshecao

Huangqi [Radix Astragali seu Hedysari

黄芪]

etc. Syndrome of stagnation of liver Qi and spleen deficiency occurred 206 times

involving 163 herbs. There were 28 herbs with use frequency more than 10%

which could be clustered into 5 categories. Combination of commonly used herbs were Chaihu

Baizhu

Fuling

Danggui

Baishao

Zhiqiao

Dangshen [Radix Codonopsis

党 参 ]

Yujin

Huangqi

Danshen

Baihuasheshecao

Huzhang

Chenpi [Pericarpium Citri Reticulatae

陈皮]

Banlan’ gen

Gancao [Radix Glycyrrhizae

甘草]. Syndrome of static blood blocking collaterals occurred 147 times

involving 151 herbs. There were 35 herbs with use frequency more than 10%

which could be clustered into 5 categories. Combination of commonly used herbs were Danshen

Chaihu

Danggui

Baishao

Baizhu

Fuling

Taoren [Semen Persicae

桃仁]

Honghua [Flos Carthami

红花]

Huangqi

Baihuasheshecao

Huzhang

Chishao

Gancao

Biejia [Carapax Trionycis

鳖甲]

Chuanshanjia [Squama Manis

穿山甲]

Yujin. Syndrome of Yin deficiency of liver and kidney occurred 142 times

involving 161 herbs. There were 30 herbs with use frequency more than 10%

which could be clustered into 6categories. Combination of commonly used herbs were Shengdihuang [Radix Rehmanniae Recens

生地黄]

Shashen[Adenophora stricta

沙参]

Maidong [Radix Ophiopogonis

麦冬]

Fuling

Baizhu

Danshen

Baihuasheshecao

Yujin

Chaihu

Danggui

Baishao

Nyuzhenzi [Fructus Ligustri Lucidi

女贞子]

Gouqizi [Fructus Lycii

枸杞子]

Huangqi. Syndrome of Yang deficiency of spleen and kidney occurred 103 times

involving 157 herbs. There were 31 herbs with use frequency more than 10%

which could be clustered into 6 categories. Combination of commonly used herbs were Fuzi [Radix Aconiti Lateralis Preparata

附子]

Huangqi

Dangshen

Baizhu

Fuling

Yinyanghuo [Herba Epimedii

淫羊藿]

Danshen

Bajitian [Radix Morindae Officinalis

巴戟天]

Chaihu

Danggui

Baishao

Shanyao[Rhizoma Dioscoreae

山药]

Baihuasheshecao

Huzhang

Yujin

Tusizi [Semen Cuscutae

菟丝子]

Gouqizi

Nyuzhenzi. Conclusion Herbs of dispersing the stagnated liver-Qi

invigorating the spleen

clearing heat

removing toxicity and promoting diuresis were commonly used in Chinese medicine syndromes of Chronic Hepatitis B. They were basic treatment methods of this disease. In addition to these treatment methods

nourishing liver and kidney or warmly invigo-rating spleen and kidney might be added.