Objective To observe the therapeutic effect of Qifu Longkui Decoction（ 芪附龙葵汤） in treating metastatic colorectal cancer. Methods Divided 59 patients with metastatic colorectal cancer into treatment group（ 30cases） and control group（ 29 cases）. The control group was given Xelox chemotherapy. In addition to the intervention for the control group

the treatment group was also given Qifu Longkui Decoction

one dose per day. For both groups

21 days were taken as one course of treatment

totally with four courses. The short-term effect

quality of life and toxic side effects in both groups were observed. Results The short term total effective rate was 63. 3% in the treatment group and 34. 5% in the control group

with significant difference（ P < 0. 05）. In the treatment group

the quality of life increased and stabilized was in 26 cases

which accounted for 86. 7%

and that in the control group was16 cases

which accounted for 55. 2%

thus

the quality of life in the treatment group was better than that in the control group（ P < 0. 05）. When comparing toxic and side effects of the two groups

bone marrow inhibition in the treatment group was 8 cases

accounting for 26. 7%

peripheral neurotoxicity was 9 cases

accounting for 30. 0%

gastrointestinal tract reaction was 7 cases

accounting for 23. 3%; and those in the control group were respectively 12 cases（ 41. 4%）

16 cases（ 55. 2%） and 16 cases（ 55. 2%）. The treatment group was superior to the control group（ P <0. 05）. Conclusion Qifu Longkui Decoction combined with Xelox regimen in treating metastatic colorectal cancer seems to have good clinical efficacy

and can improve patients’ quality of life and reduce the side effects of chemotherapy.