This article adopted traditional literature and mathematical statistics methods

in order to explore the dose feature of 13 doctors in Ming Dynasty in applying Huanglian [Coptis chinensis] in clinic and its indications. The authors concluded that Huanglian is the frequently-used clearing-heat herb for doctors in Ming Dynasty. The average dose of Huanglian in Ming Dynasty was about 4. 8 g

with the most common dose about 3. 7 g

the biggest dose 18. 5 g and the frequently-used dose range 0. 7

18. 5 g. Different doctors used different dose. In Ming Dynasty

Huanglian was mainly used in treating various diseases

including epigastric fullness syndrome

phlegm syndrome

blood syndrome

dysentery

diarrhea

consumptive heat

emesis

tympanites

sore ulcer and epidemic toxic heat. In general

the feature of doctors in Ming Dynasty in applying Huanglian was wide application and flexible compatibility.