Objective To analyze the medication rules of Chinese medicine expert Professor LIU Shangyi treating cancer adopting data mining technology and to summarize the academic experience of Prof. LIU Shangyi diagnosing and treating cancer. Methods One thousand two hundred and twenty cancer patients were collected

who went to Prof. LIU Shangyi’ s clinic at Guo Yi Tang（ 国 医 堂） from August of 2013 to April of 2014. Herb use frequency

patients’ name

gender and the type of cancer were made statistics by Auxiliary System of Chinese Medicine Inheritance V2. 5. Association rules and complex system entropy clustering analysis were adopted. Results Totally

234 herbs were used on 1220 patients. There were 25 herbs in total with use frequency more than 100 times. Top five herbs were Ezhu [Rhizoma Curcumae ]（ 1207）

Biejia [Carapax Trionycis ]（ 1203）

Donglingcao [Rabdosiarubescens]（ 1147）

Lyucaohua [Humulus japonicas flower]（ 502） and Shengdihuang [Radix Rehmanniae Recens]（345）. Top five herb combinations with high use frequency were Biejia-Ezhu（1201）

Ezhu-Donglingcao（1129）

Biejia-Donglingcao（ 1126）

Ezhu-Biejia-Donglingcao（ 1124） and Donglingcao-Lyucaohua（ 404）. Based on improved mutual information method

top 5 herbs with high inter herb association were Shudihuang [Radix Rehmanniae Preparata]-Yiyiren [Semen Coicis]（ 0. 023183）

Shudihuang-Huanglian [Rhizoma Coptidis]（ 0. 016410）

Shengdihuang-Muxiang [Radix Aucklandiae]（ 0. 015598）

Shanzhuyu [Fructus Corni]-Muxiang（ 0. 015379） and Yuzhu[Rhizoma Polygonati Odorati]-Houpo [Cortex Magnoliae Officinalis]（0. 015181）. Based on complex system entropy clustering

herb core combinations were 16 groups in total

mainly including Yujin [Radix Curcumae]-Ziwan[Radix Asteris]-Foshou [Fructus Citri Sarcodactylis]

Zhimahuang [Herba Ephedrae stir-frying with honey]-Manjingzi [Fructus Viticis]-Sangbaipi [Cortex Mori ]

Yinchen [Herba Artemisiae Scopariae]-Qiancao [Radix Rubiae]-Liujinu [anomalous artemisia]

Cangerzi [Fructus Xanthii]-Gancao [Radix Glycyrrhizae]-Jiegeng [Radix Platycodonis]

Fabanxia [Rhizoma Pinelliae Preparatum]-Gualoupi [Pericarpium Trichosanthis]-Huanglian

Dongkuizi [Fructus Malvae]-Bixie [Rhizoma Dioscoreae Hypoglaucae]-Tufuling [Rhizoma Smilacis Glabrae ]

Donglingcao-Ezhu-Lyucao [Humulus japonicus]-Biejia

Shudihuang-Huangqi [Radix Astragali seu Hedysari]-Shanzhuyu-Shihu [Herba Dendrobii]. Conclusion Prof. LIU Shangyi mainly uses herbs of benefiting Qi

nourishing blood and strengthening vital Qi to treat cancer

combining with removing blood stasis and anticancer herbs. The academic characteristics of Prof. LIU Shangyi "treating cancer from ulcer theory"and "treating from membrane"were confirmed by herbs analysis.