LI Jiansheng, WANG Zhiwan, YU Xueqing, et al. Initial Validation of Diagnostic Criterion of Bronchial Asthma Syndrome[J]. Journal of Traditional Chinese Medicine2016, 57(20): 1772-1776.
LI Jiansheng, WANG Zhiwan, YU Xueqing, et al. Initial Validation of Diagnostic Criterion of Bronchial Asthma Syndrome[J]. Journal of Traditional Chinese Medicine2016, 57(20): 1772-1776.DOI: 10.13288/j.11-2166/r.2016.20.015.
Initial Validation of Diagnostic Criterion of Bronchial Asthma Syndrome
Objective To initially verify diagnostic efficiency of diagnostic criterion of bronchial asthma syndrome established in this project. Methods Foresight research methods was adopted to collect information of 300 cases of bronchial asthma from four grade Ⅲ
class A hospitals and to establish a database. "Questionnaire of Chinese Medicine Syndrome of Bronchial Asthma Diagnosis"was used to investigate distribution of 10 syndromes in patients
including cold in the exterior and fluid retention syndrome
phlegm-turbid obstruction lung syndrome
phlegm-heat obstructing lung syndrome
wind-phlegm blocking lung syndrome
blood stasis syndrome
lung Qi deficiency syndrome
lung and spleen Qi deficiency syndrome
lung and kidney Qi deficiency syndrome
lung and kidney Yang deficiency syndrome
and sudden loss of Yang-Qi syndrome. At the same time
syndrome differentiation was conducted by experienced Chinese medical experts
and the results from both investigation and clinical experts were compared.Sensitiveness
specificity
accuracy
positive predictive value
negative predictive value
positive likelihood ratio
negative predictive value
and area under the curve were selected as the evaluation indices. Results Three hundred questionnaires were distributed and they were all returned back as valid ones. Among them
there were 200 in acute attack
30 in chronic persistent stage
and 70 in clinical remission. Among 10 common syndromes with sensitiveness range of 78. 26%- 98. 48%
blood stasis syndrome was with the highest sensitiveness( 98. 48%) and sudden loss of Yang-Qi syndrome with the lowest sensitiveness( 78. 26%); the specificity range was 90. 64%- 99. 15% and blood stasis syndrome was with the highest specificity among them( 99. 15%); the accuracy range was 90. 67%-99. 00% and blood stasis syndrome was with the highest accuracy among them( 99. 00%); the positive predictive value range was 60. 98%- 97. 01%; the negative predictive value range was 95. 38%- 99. 57%; the positive likelihood ratio range was 9. 70- 115. 23; and the negative likelihood ratio range was 0. 02- 0. 23. The range of area under the curve of receiver operating characteristic was 0. 803- 0. 954
and the area under the curve of blood stasis syndrome was the biggest one( 0. 954)
followed by that of phlegm-heat obstructing lung syndrome( 0. 913) and phlegm-turbid obstruction lung syndrome( 0. 901). Areas under the curve of lung and kidney Qi deficiency syndrome( 0. 803) and sudden loss of Yang-Qi syndrome( 0. 809) were small. Conclusion The diagnostic criterion of syndrome of bronchial asthma has good sensitiveness
specificity and accuracy. The diagnostic efficiency of the criterion is better for excess syndromes than for deficiency syndromes. In excess syndrome
blood stasis syndrome is with the best diagnosis efficiency
followed by phlegm-heat obstructing lung syndrome and phlegm-turbid obstruction lung syndrome.
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Related Author
Project Group of Specification for Traditional Chinese Medicine Syndrome Diagnosis of Heart Failure, China Association of Chinese Medicine
SUN Ying
HU Haibo
LIU Na
WANG Fengchan
ZONG Jinbao
HAN Ping
LI Peng
Related Institution
First Clinical Medical College,Shandong University of Traditional Chinese Medicine
Qingdao Traditional Chinese Medicine Hospital (Qingdao Hiser Hospital)
Qingdao Traditional Chinese Medicine Hospital
The First Clinical Medical College of Shandong University of Traditional Chinese Medicine
The First Hospital of Hunan University of Chinese Medicine