The formation of mindset in Yellow Emperor’s Inner Canon（ 黄帝内经） is deeply influenced by Pre-Qin cultural thought. That mindset comes down in one continuous line with the mindset under the culture background at that time. The holistic thinking in Yellow Emperor’s Inner Canon（ 黄帝内经） mainly embodies that it combines fivephase theory and harmony of man with nature thought. Five Zang viscera and four seasons are linked. Thus the "four seasons-five Zang viscera-Yin Yang"system is established. The syndrome differentiation thought is greatly affected by Taoism Lao Tzu thought and Confucianism Yi Zhuan（ 易传）. Dialectical category of Yin and Yang or dynamic dialectical proposition could find the source of thought in Taoism and Confucianism. Image thinking is consistent with point of view in "Chuzhenxun"in Huainanzi（ 淮南子·俶真训） and the interpretation is vivid. Understanding "spirit"in intuitive thought is similar to understanding "Dao"（ 道） in Taoism. Thus it is influenced by intuitive thought in Taoism. While the ways of understanding of "idea " or "insight " is similar to "dedicated to enlightenment " in Confucianism.