Objective To evaluate the therapeutic effect of Reduning Injection（ 热毒宁注射液） in treating children with hand-foot-and-mouth disease（ HFMD）. Methods Retrieved China Journal Full-text Database

VIP Chinese scientific journals database

Wanfang database

Chinese Master Theses Full-text Database

and selected the randomized controlled trials about Reduning Injection in the treatment of children with HFMD. The retrieval time for each database is from establishing time of each database to December 2015. Using the modified Jadad scale to evaluate the quality of literature

the researchers conducted meta-analysis of the fever clearance time

skin rash subsiding time

oral herpes regression time

clinical efficiency for all the selected modern literature. Results A total of 7literatures were included with Jadad scores more than or equal to 3 points. When treating HFMD

Reduning Injection is better than ribavirin in fever clearance time [WMD =- 1. 38

95% CI（- 1. 83

- 0. 93）

Z = 6. 04

P <0. 001]

skin rash subsiding time [WMD =- 1. 83

95% CI（- 2. 32

- 1. 34）

Z = 7. 35

P < 0. 001 ]

oral herpes regression time [WMD =- 2. 06

95% CI(- 2. 18

- 1. 93

Z = 31. 89

P < 0. 001] and clinical efficiency [RR = 1. 23

95% CI（ 1. 15

1. 33）

P < 0. 001]. There was no obvious or serious adverse reaction

and there was low possibility of publication bias. Conclusion Reduning Injection is superior to ribavirin in clinical symptom improvement and clinical efficiency of children HFMD.