Observation on Clinical Effects of Chinese Medicine Assisted Arterial Infusion Chemotherapy in the Treatment of 53 Cases of Advanced Non-Small Cell Lung Cancer

XU Yongmei; YANG Guowang; HU Fengshan; HAN Dong; CHEN Xinyi; WU Jie; LIU Sheng; FAN Qingsheng

doi:10.13288/j.11-2166/r.2017.02.012

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Observation on Clinical Effects of Chinese Medicine Assisted Arterial Infusion Chemotherapy in the Treatment of 53 Cases of Advanced Non-Small Cell Lung Cancer

更新时间：2021-11-10

- Observation on Clinical Effects of Chinese Medicine Assisted Arterial Infusion Chemotherapy in the Treatment of 53 Cases of Advanced Non-Small Cell Lung Cancer
- Journal of Traditional Chinese Medicine Vol. 58, Issue 2, Pages: 138-142(2017)
- 作者机构：
  
  1. 首都医科大学附属北京中医医院
  2. 北京中医药大学东直门医院
  3. 中国中医科学院广安门医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2017.02.012
  CLC： R734.2
- Published：2017
- 稿件说明：
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[1]徐咏梅,杨国旺,胡凤山,韩冬,陈信义,吴洁,刘声,樊庆胜.中药辅助动脉灌注化疗治疗晚期非小细胞肺癌53例临床疗效观察[J].中医杂志,2017,58(02):138-142.

XU Yongmei, YANG Guowang, HU Fengshan, et al. Observation on Clinical Effects of Chinese Medicine Assisted Arterial Infusion Chemotherapy in the Treatment of 53 Cases of Advanced Non-Small Cell Lung Cancer[J]. Journal of Traditional Chinese Medicine2017, 58(2): 138-142.
[1]徐咏梅,杨国旺,胡凤山,韩冬,陈信义,吴洁,刘声,樊庆胜.中药辅助动脉灌注化疗治疗晚期非小细胞肺癌53例临床疗效观察[J].中医杂志,2017,58(02):138-142. DOI： 10.13288/j.11-2166/r.2017.02.012.

XU Yongmei, YANG Guowang, HU Fengshan, et al. Observation on Clinical Effects of Chinese Medicine Assisted Arterial Infusion Chemotherapy in the Treatment of 53 Cases of Advanced Non-Small Cell Lung Cancer[J]. Journal of Traditional Chinese Medicine2017, 58(2): 138-142. DOI： 10.13288/j.11-2166/r.2017.02.012.

摘要

目的观察动脉灌注化疗联合中药治疗晚期非小细胞肺癌（NSCLC）的有效性和安全性。方法将106例晚期NSCLC患者随机分为治疗组和对照组各53例。对照组采用全身化疗方案

治疗组采用动脉灌注化疗+口服中药汤剂治疗

两组均以21天为1个周期

连续治疗3个周期。治疗前后检测两组患者的体质量及Karnofsky评分

并比较两组患者临床疗效及化疗所致不良反应的发生情况。结果治疗组完全缓解2例、部分缓解30例、疾病稳定17例、疾病进展4例、客观缓解率60.38%、临床获益率92.45%

对照组分别为1例、22例、25例、5例、43.40%、90.57%

治疗组客观缓解率高于对照组（P<0.05）

临床获益率两组比较差异无统计学意义（P>0.05）。两组患者治疗前后体质量比较差异无统计学意义（P>0.05）

治疗组患者治疗后Karnofsky评分较本组治疗前及对照组治疗后均升高（P<0.05）。两组患者不良反应主要为脱发、白细胞下降、恶心呕吐

治疗组白细胞减少发生率明显低于对照组（P<0.05）

其余不良反应两组比较差异无统计学意义（P>0.05）。结论中药辅助动脉灌注化疗可提高晚期NSCLC患者的生活质量、减轻化疗毒副反应

且效果优于单纯全身化疗。

Abstract

Objective To observe the efficacy and safety of Chinese medicine assisted arterial infusion chemotherapy in the treatment of advanced non-small cell lung cancer（ NSCLC）. Methods One hundred and six cases of advanced NSCLC were randomized into a treatment group and a control group

with 53 cases in each. The control group adopted systemic chemotherapy

and the treatment group was treated with arterial infusion chemotherapy and oral Chinese herbal decoction. Both groups adopted 3 treatment cycles continuously

with 21 days as one cycle. The body mass and Karnofsky score of patients in each group were measured before and after treatment

and the clinical efficacy and occurrence of adverse reaction induced by chemotherapy were compared. Results In the treatment group

there were 2 cases of complete remission（ CR）

30 of partial remission（ PR）

17 of stable disease（ SD） and4 of progressive disease（ PD）; the objective response rate（ ORR） was 60. 38%

and the clinical benefit rate（ CBR）was 92. 45%. In the control group

the counterparts were 1

43. 40% and 90. 57% respectively. The ORR of the treatment group was higher than that of the control group（ P < 0. 05）

and there was no statistically significant difference in CBR between the two group（ P > 05）. Before and after treatment

there was no statistical significance weight difference in body mass between the two groups（ P > 05）. The Karnofsky score in the treatment group after treatment was higher than that before treatment as well as that of the control group after treatment（ P < 0. 05）.The adverse reactions in both groups were mainly hair loss

leukocyte decrease

nausea and vomiting. The incidence rate of leukocyte decrease in the treatment group was significantly lower than that in the control group（ P < 0. 05）.There were no statistically significant differences in the incidence rates of another two adverse reactions between the two group（ P > 05）. Conclusion Chinese medicine assisted arterial infusion chemotherapy could improve the quality of life of the patients with advanced NSCLC and reduce the toxic side effects induced by chemotherapy

and its efficacy seems better than systemic chemotherapy alone.

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