Objective To explore the possible mechanism of electroacupuncture in treating remission migraine and the effect of acupoints compatibility. Methods Thirty rats were randomized into a control group

a model group

a single point group

a compatibility points group

and a sham points group

with 6 rats in each group.Besides the control group

remission migraine models were established in rats in other groups by electrical stimulation of the dura mater after surgery of electrode operation for intracranial apical drilling. The single point group was given electroacupuncture at bilateral Point Fengchi（ GB20）. The compatibility points group was given electroacupuncture at bilateral Points Fengchi（ GB20） and Yanglingquan（ GB34）. The sham points group was given electroacupuncture at non acupoints at the waist. On the 2nd

4th and 6th day after modeling

rats were given electroacupuncture under conscious state. Pain threshold value of pelma and face was examined. On the 7th day

the expressions of5-hydroxytryptamine 1F receptor（ 5-HT1F） mRNA and proteins in rats brain trigeminal ganglion

spinal trigeminal caudal nucleus and nucleus raphe magnus were detected. Results On the 2nd

4th and 6th day

the pain threshold value of face and pelma of rats in the model group was lower than that in the control group at the same time（ P <0. 05）

that in the single point group and the compatibility points group were higher than that in the model group at the same time（ P < 0. 05）

and that in the single point group was lower than that in the compatibility points group at the same time but higher than that in the sham points group at the same time（ P < 0. 05）. The expressions of 5-HT1 F receptor mRNA and proteins in brain trigeminal ganglion

spinal trigeminal caudal nucleus and nucleus raphe magnus of rats in the model group were lower than those in the control group（ P < 0. 05）; 5-HT1 F receptor mRNA and proteins of all the sites in the single point group and the compatibility points group were higher than those in the model group

and those in the compatibility points group were higher than those in the single point group（ P < 0. 05）.Conclusion The mechanism of electroacupuncture treating remission migraine might be related to 5-HT1 F receptor activation. The effect of near-far point compatibility seems superior to single point treatment.