Pathogenesis is the basis of Chinese medicine theory research

with a certain hierarchy. According to different standards

it is divided in different levels. This article is to explain the connotation and relationship among symptom pathogenesis

syndrome pathogenesis and disease pathogenesis

especially emphasizing the importance of disease pathogenesis. The disease pathogenesis of diabetic nephropathy is that Yin-essence loss leads to deficiency of vital gate genuine Yin and then results in secondary inadequate sources of kidney Qi

kidney Yin and kidney Yang.As for treatment

invigorating genuine Yin should be carried out. The syndrome pathogenesis is the "deficiency-Qi causing stagnation"pathogenesis which means deficiency of kidney Qi

kidney Yin and kidney Yang leading to pathogen and excess stagnation

such as phlegm-damp

blood stasis. The authors emphasize that healthy Qi deficiency is the premise of pathogen stagnation. As for treatment

strengthening vital Qi is emphasized to eliminate pathogenic factor. The symptom pathogenesis is the external direct pathogenesis

which is the basis of syndrome and disease differentiation.