Objective To explore the difference of syndrome differentiation and acupuncture prescription between doctors.Methods The study objects were the cancer patients who had nausea and vomit after chemotherapy

and acupuncture was selected as the therapeutic method.Two doctors independently differentiated syndrome of the same patient by four diagnostic methods and conducted specific acupuncture protocols

including point selection

needling depth

manipulation strength

reinforcement and reduction

and the time of retaining needle.The consistency of syndrome differentiation was measured by Kappa test

and the differences between doctors were compared.Results The consistency of syndrome differentiation was low（ consistency 38.5%

k = 0.22）

but the points selected were basically same.The master points were Zhongwan（ RN 12）

Tianshu（ ST 25

bilateral）

Neiguan（ PC 6

bilateral）

and Zusanli（ ST 36

bilateral）

and there was no significant difference in points selected（ χ2= 8.746

P =0.724）.But there were significant differences in the manipulation strength

needling depth

time of retaining needle

and the reinforcement and reduction between the two doctors’ protocols（ P < 0.05）.Conclusion For the cancer patients with nausea and vomit after chemotherapy

the consistency of syndrome differentiation between doctors was low

which had minimal effect on point selection.The main difference was reflected in the manipulation methods.