Objective To explore clinical character

distribution rule of Chinese medicine syndrome and pathogenesis evolution law of primary biliary cirrhosis. Methods Collected 96 patients with primary biliary cirrhosis presented at Beijing Ditan Hospital

from June 2012 to September 2014. Surveyed and recorded common condition

main syndrome and signs

Chinese medicine diagnostic information of the patients. Counted symptoms and syndrome distribution character in different disease phases

including chronic hepatitis

liver fibrosis and cirrhosis of the liver.Results In 96 patients

the syndrome elements of disease location were mainly liver

spleen and kidney

partly involving gallbladder; there were 10 kinds of disease syndrome nature

with the top 5 frequent elements being Qi deficiency（78）

Qi stagnation（64）

dampness（48）

Yin deficiency（34）

blood stagnation（33） successively.Dampness and heat were relatively less prominent; there were 10 kinds of viscera disorder syndrome elements

and the top five were spleen deficiency（63）

liver stagnation（57）

liver Yin deficiency（23）

kidney Yin deficiency（23）

kidney deficiency（29）

spleen Yang deficiency（3） successively. Syndrome elements of disease location in different disease process were all mainly liver and spleen

with kidney involved in later period; in disease nature

Qi deficiency and Qi stagnation went through the whole process while Yin deficiency and blood stagnation worsened gradually. Dampness and heat stood out the most in liver cirrhosis; as for viscera disorders

spleen deficiency and liver stagnation were the highest in the whole process

with liver Yin deficiency and blood stagnation worsened gradually

among which spleen deficiency was the most prominent. Conclusion Qi deficiency

Qi stagnation

Yin deficiency and blood stasis stood out in patients with primary biliary cirrhosis

and liver

spleen and kidney stood out in disease location.