Objective To review the effect and safety of Yishen Juanbi Capsule in treating rheumatoid arthritis（ RA） systematically. Methods Randomized controlled trials about Yishen Juanbi Capsule treating RA were reviewed in China National Knowledge Infrastructure

VIP Database

Wanfang Database

Pub Med and Cochrane Library. The methodology quality of included papers was evaluated. Rev Man 5. 0 software was adopted to make Meta analysis. The evaluation indexes included clinical effect evaluation

Chinese Medicine syndrome effect evaluation and safety evaluation. Results Four papers met the standard were included

about 1784 patients. No papers used blind method

nor did the papers introduce allocation concealment method. Meta analysis showed that the total clinical efficacy in the Yishen Juanbi Capsule（ or combined with other medicine） group was superior to that in the control group[RR = 1. 20

95% CI（ 1. 13

1. 27） ]; the improvement of C-reactive protein（ CRP） [SMD =-1. 03

95% CI（-1. 18

-0. 89） ] and total score of Chinese medicine symptom [SMD =-0. 56

95% CI（-0. 78

-0. 34） ]in the treatment group was superior to that in the control group. There were no other serious adverse reactions and other safety problems except individual gastrointestinal reaction record. Conclusion Yishen Juanbi Capsule treating RA might be effective

without obvious adverse reactions. As for improving other indexes

more high-quality researches were needed to make further analysis and demonstration.