Objective To explore the Chinese medicine syndrome evolution characteristics of acute exacerbationrisk window-stationary phase of chronic obstructive pulmonary disease（ COPD）. Methods Totally 500 COPD patients（ acute exacerbation

risk window and stationary phase） from 8 hospitals were collected. Chinese medicine syndrome clinical research questionnaires of acute exacerbation of COPD（ AECOPD） and risk window were made.The survey included patients’ general demographic data

disease related indexes and Chinese medicine four diagnostic information indexes. The basic syndrome

distribution of clinical syndrome and the evolution in COPD acute exacerbation

risk window and stationary phase were examined and recorded. Results Questionnaires in acute exacerbation and risk window recalled were both 406. Questionnaires in stationary phase were 370. 1) Nature of disease. In acute exacerbation of COPD

deficiency-excess ratio of disease nature was 1 ∶ 2. 86. The main syndrome was excess. In risk window

the ratio was 1 ∶ 1. 06. The main syndrome was intermingled deficiency and excess. In stationary phase

the ratio was 1 ∶ 0. 09. The main syndrome was deficiency. 2) Location of disease. Six main syndromes in acute exacerbation were phlegm-heat obstructing lung

phlegm-damp obstructing lung

external cold and internal fluid

phlegm-heat obstructing lung with Qi deficiency of lung and kidney

phlegm-heat obstructing lung with blood stasis

as well as phlegm-damp obstructing lung with Qi deficiency of lung and spleen. In acute exacerbation

the location of disease was mainly lung. After going to risk window

new disease location heart and spleen increased.After going to stationary phase

common disease locations were lung-kidney and lung-spleen. In acute exacerbation

there were 54 syndromes recorded

53 in risk window

and 44 in stationary phase. Conclusion In acute exacerbation of COPD

the main syndrome was excess syndrome; the main disease location was lung. In risk window

the syndrome was intermingled deficiency and excess; the disease locations were lung

spleen and kidney. In stationary phase

the main syndrome was deficiency syndrome; the disease locations were lung

spleen and kidney. The results reflected the clinical characteristics of asthenia in origin and asthenia in superficiality of this disease.