Effect of Huwei San （护胃散） on Expression of VEGF and bFGF mRNA in Gastric Mucosa of Rats with Rush Entry into Plateau

LI Junru; JIA Shouning; YANG Cuilan; CAO Shenghai; ZOU Xiaoyun; WANG Shuangxi; LI Xin; LI Yawei

doi:10.13288/j.11-2166/r.2017.09.017

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Effect of Huwei San （护胃散） on Expression of VEGF and bFGF mRNA in Gastric Mucosa of Rats with Rush Entry into Plateau

更新时间：2021-11-10

- Effect of Huwei San （护胃散） on Expression of VEGF and bFGF mRNA in Gastric Mucosa of Rats with Rush Entry into Plateau
- Journal of Traditional Chinese Medicine Vol. 58, Issue 9, Pages: 787-790(2017)
- 作者机构：
  
  青海省中医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2017.09.017
  CLC： R285.5
- Published：2017
- 稿件说明：
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[1]李军茹,贾守宁,杨翠兰,曹生海,邹小云,王双玺,李欣,李亚伟.护胃散对急进高原大鼠胃黏膜VEGF和bFGF mRNA表达的影响[J].中医杂志,2017,58(09):787-790.

LI Junru, JIA Shouning, YANG Cuilan, et al. Effect of Huwei San （护胃散） on Expression of VEGF and bFGF mRNA in Gastric Mucosa of Rats with Rush Entry into Plateau[J]. Journal of Traditional Chinese Medicine2017, 58(9): 787-790.
[1]李军茹,贾守宁,杨翠兰,曹生海,邹小云,王双玺,李欣,李亚伟.护胃散对急进高原大鼠胃黏膜VEGF和bFGF mRNA表达的影响[J].中医杂志,2017,58(09):787-790. DOI： 10.13288/j.11-2166/r.2017.09.017.

LI Junru, JIA Shouning, YANG Cuilan, et al. Effect of Huwei San （护胃散） on Expression of VEGF and bFGF mRNA in Gastric Mucosa of Rats with Rush Entry into Plateau[J]. Journal of Traditional Chinese Medicine2017, 58(9): 787-790. DOI： 10.13288/j.11-2166/r.2017.09.017.

摘要

目的探讨护胃散治疗急进高原胃黏膜损伤的可能作用机制。方法 350只Wistar大鼠随机分为北京组、西宁组、玛多空白组、玛多阳性对照组和护胃散高、中、低剂量组

每组50只。除北京组外

余300只大鼠空运至西宁市

玛多空白组、玛多阳性对照组和护胃散高、中、低剂量组当日继续由汽车运至玛多县。北京组、西宁组、玛多空白组灌服生理盐水2 ml

玛多阳性对照组给予荆花胃康胶丸2.4 g/（kg·d）

护胃散低、中、高剂量组分别给予护胃散2.6、5.2、10.4 g/（kg·d）

共计7天。各组分别于实验第1、2、3、5、7天处死10只大鼠

取胃黏膜组织进行病理观察

同时测定胃黏膜血管内皮生长因子（VEGF）和碱性成纤维生长因子（bFGF）mRNA表达。结果玛多空白组大鼠胃黏膜表面散在出血点、糜烂或浅表溃疡

局部黏膜有缺损改变;护胃散高剂量组黏膜下血管淤血、炎性渗出等较玛多空白组有较大改善。与玛多空白组同时间比较

护胃散中、高剂量组在第3、5天有不同程度的VEGF、bFGF mRNA表达升高

且护胃散高剂量组在第2、3天VEGF mRNA表达升高优于玛多阳性对照组（P<0.05或P<0.01）。结论护胃散可提高急进高原大鼠胃黏膜中VEGF及bFGF mRNA的表达

从而促进急进高原胃黏膜损伤的修复。

Abstract

Objective To explore possible mechanism of Huwei San（护胃散） in treating gastric mucosal injury in rush entry into plateau. Methods Randomly divided 350 Wistar rats into Beijing group

Xining group

Madoi blank group

Madoi positive control group and Huwei San high

middle and low dose groups

with 50 rats in each group. Except for Beijing group

the other 300 rats were delivered to Xining city by air. The Madoi blank group

Madoi positive control group and Huwei San high

middle and low dose groups were successively delivered to Madoi County by bus on that day. Beijing group

Xining group and the Madoi blank group were perfused with 2ml saline.Madoi positive control group was given Jinghua Weikang Capsule（荆花胃康胶丸） 2. 4 g/（ kg·d）. Huwei San low

middle and high dose group were respectively given Huwei San of 2. 6 g/（ kg·d）

5. 2 g/（ kg·d） and 10. 4 g/（ kg·d）

for 7 days totally. Ten rats in each group were sacrificed on the 1st

2nd

3rd

5th and 7th day of the experiment. Took gastric mucosal tissue and conducted pathological observation. At the same time

examined the expression of mRNA of vascular endothelial growth factor（ VEGF） and basic fibroblast growth factor（ bFGF） in gastric mucosa.Results There were scattered hemorrhagic spots

erosion or superficial ulcer in surface of gastric mucosa and defect change in local mucosa of rats in the Madoi blank group; congestion and inflammation exudation in submucosal vessels in the Huwei San high dose group improved much compared with the Madoi blank group. Compared with that in the Madoi blank group at the same time

there were different levels of expression increase of VEGF

and bFGF mRNA in the Huwei San high and middle dose groups on the 3rd and 5th day. And on the 2nd and 3rd day

the expression increase of VEGF mRNA in the Huwei San high dose group was superior to the Madoi positive control group（ P < 0. 05 or P < 0. 01）. Conclusion Huwei San could increase the expression of VEGF and bFGF mRNA in gastric mucosa of rats with rush entry into plateau. Thus it could improve repair of gastric mucosal injury in rush entry into plateau.

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