Clinical Observation on 46 Angina Pectoris Patients after Percutaneous Coronary Intervention Treated with Yiqi Huoxue Jiedu Fang（益气活血解毒方） Combined with Western Medicine

YANG Jinlong; DING Shuwen; YAO Xiaodong; WANG Yan; YU Xiaohua; LI Xiao

doi:10.13288/j.11-2166/r.2017.10.011

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Clinical Observation on 46 Angina Pectoris Patients after Percutaneous Coronary Intervention Treated with Yiqi Huoxue Jiedu Fang（益气活血解毒方） Combined with Western Medicine

更新时间：2021-11-10

- Clinical Observation on 46 Angina Pectoris Patients after Percutaneous Coronary Intervention Treated with Yiqi Huoxue Jiedu Fang（益气活血解毒方） Combined with Western Medicine
- Journal of Traditional Chinese Medicine Vol. 58, Issue 10, Pages: 850-853(2017)
- 作者机构：
  
  1. 山东中医药大学附属医院
  2. 济南市市中区人民医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2017.10.011
  CLC： R541.4
- Published：2017
- 稿件说明：
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[1]杨金龙,丁书文,姚晓东,王燕,于潇华,李晓.益气活血解毒方联合西药治疗经皮冠状动脉介入治疗术后心绞痛患者46例临床观察[J].中医杂志,2017,58(10):850-853.

YANG Jinlong, DING Shuwen, YAO Xiaodong, et al. Clinical Observation on 46 Angina Pectoris Patients after Percutaneous Coronary Intervention Treated with Yiqi Huoxue Jiedu Fang（益气活血解毒方） Combined with Western Medicine[J]. Journal of Traditional Chinese Medicine2017, 58(10): 850-853.
[1]杨金龙,丁书文,姚晓东,王燕,于潇华,李晓.益气活血解毒方联合西药治疗经皮冠状动脉介入治疗术后心绞痛患者46例临床观察[J].中医杂志,2017,58(10):850-853. DOI： 10.13288/j.11-2166/r.2017.10.011.

YANG Jinlong, DING Shuwen, YAO Xiaodong, et al. Clinical Observation on 46 Angina Pectoris Patients after Percutaneous Coronary Intervention Treated with Yiqi Huoxue Jiedu Fang（益气活血解毒方） Combined with Western Medicine[J]. Journal of Traditional Chinese Medicine2017, 58(10): 850-853. DOI： 10.13288/j.11-2166/r.2017.10.011.

摘要

目的观察益气活血解毒方治疗经皮冠状动脉介入治疗（PCI）术后心绞痛的临床疗效。方法选择PCI术后心绞痛患者91例

随机分为治疗组46例

对照组45例。两组患者均给予基础治疗

对照组再给予养心氏片

每次1.8 g

每日3次;治疗组再给予益气活血解毒方

每日1剂。两组疗程均为4周。治疗后观察两组患者心绞痛、心电图及中医证候疗效

治疗前后检测总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、超敏C反应蛋白（hs-CRP）及白细胞介素6（IL-6）。结果治疗组心绞痛、心电图及中医证候疗效总有效率分别为86.96%、69.57%、93.48%

对照组分别为68.89%、46.67%、77.78%

治疗组均优于对照组（P<0.05或P<0.01）。两组患者治疗后与治疗前比较

TC、TG、LDL-C、hs-CRP、IL-6水平降低

HDL-C升高（P<0.01）

且治疗后治疗组较对照组hs-CRP、IL-6水平降低明显（P<0.01）。结论益气活血解毒方能够缓解PCI术后心绞痛

抑制炎症反应

从而保护血管内皮功能。

Abstract

Objective To observe the clinical efficacy of Yiqi Huoxue Jiedu Fang in treating angina pectoris patients after percutaneous coronary intervention（PCI）. Methods Ninety one cases of angina pectoris patients after PCI were randomly divided into treatment group（46 cases） and control group（45 cases）. The two groups were both given basic treatment. In addition

the control group was given Yangxinshi Tablet（养心氏片）

1. 8 g each time

three times daily. Treatment group was given Yiqi Huoxue Jiedu Fang

1 dose daily. The two groups both were treated for 4 weeks. After treatment

the efficacy for angina pectoris

electrocardiogram and Chinese medical syndrome in the two groups were observed separately. Changes in levels of total cholesterol（TC）

triglyceride（TG）

low density lipoprotein cholesterol（LDL-C）

high density lipoprotein cholesterol（HDL-C）

high sensitivity C reactive protein（hs-CRP） and interleukin-6（IL-6） were separately tested before and after treatment. Results The total effective rates of the efficacy for angina pectoris

electrocardiogram and Chinese medicine syndrome in treatment group were86. 96%

69. 57% and 93. 48% respectively. The effective rates in control group were 68. 89%

46. 67% and77. 78% respectively. The effective rates in treatment group were all higher than those in control group（P < 0. 05 or P < 0. 01）. In the two groups

the levels of TC

LDL-C

hs-CRP and IL-6 after treatment were lower than those before treatment

and the level of HDL-C after treatment was higher than that before treatment（P < 0. 01）. After treatment

the levels of hs-CRP and IL-6 were significantly decreased in treatment group compared with those in control group（P < 0. 01）. Conclusion Yiqi Huoxue Jiedu Fang could alleviate angina pectoris after PCI and restrain inflammation to protect the function of vascular endothelium.

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Chinese Medical College，Tianjin University of Traditional Chinese Medicine

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School of Postgraduates，Tianjin University of Traditional Chinese Medicine

The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion

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