Objective To explore the possible molecular mechanism of Shenqi Compounds（参芪复方） in preventing and treating diabetic great vascular complications. Methods Totally 160 Goto-Kakizaki（GK） rats with spontaneous type 2 diabetes were given high-fat diet for 12 weeks to establish diabetic great vascular complications model.The rats were then randomly divided into model group

western medicine group

Shenqi high

middle and low groups

with 32 rats in each group. Other 32 Wistar rats were set as blank group. After modeling

the western medicine group was given 0. 1 g/（kg·d） of diformin tablet for gavage

while the Shenqi high

middle and low groups were respectively given 2. 88

1. 44 or 0. 72 g/（kg·d） of Shenqi Compounds for gavage. The blank and model group were given5 ml/（kg·d） of saline for gavage. The medication were all for 16 weeks. Fasting blood-glucose was examined before giving medicine and in the 8th and 16 th week during treatment. In the 8th and 16 th week

Masson stain was adopted to observe pathomorphism of thoracic aorta and calculated perivascular circuferential area/lumen area（PVCA/LA）.Differential genes screening was conducted in the 16 th week. Results Compared with the blank group at the same time point

fasting blood-glucose of rats increased before and in the 8th and 16 th week during giving medicine

and PVCA/LA remarkably increased in the 8th and 16 th week in the model group（P < 0. 05 or P < 0. 01）; In the 16 th week

fasting blood-glucose of rats in the western medicine group and Shenqi high

middle and low groups were lower than that in the model group at the same time point and PVCA/LA all remarkably decreased（P < 0. 05 or P < 0. 01）.There were in total 15 remarkable common differential genes between the Shenqi middle group and the model group

and the model and the blank group. Among them

Elavl1 and Lama4 were genes that had relationship with diabetic great vascular complications. Elavl1 and Lama4 genes in the Shenqi middle group decreased. Conclusion The possible functional mechanism of Shenqi Compounds in preventing and curing diabetic great vascular complications might be related with down-regulating Elavl1 and Lama4 gene expression in thoracic aorta and therefore inhibiting angiogenesis and reducing collagen fibers producing.