Objective To explore the possible mechanism of Xiaoyin Jiedu Granules（ 消银解毒颗粒） in the treatment of psoriasis. Methods The Jurkat cell was administered by both phytohemagglutinin（ PHA） and interleukin6（ IL-6） to induce the model of psoriasis T cell abnormal proliferation. The optimal pharmaceutical serum concentration was made and selected to be applied to the cell model. The cell viability was measured with cell viability kit（ CCK-8）

and the apoptosis was detected with flow cytometry. Results When the pharmaceutical serum concentration was 20%

the inhibition rates in the Xiaoyin Jiedu Granules group and Liangxuefang group were significantly higher than that in the Jiedufang group

Acitretin group and distilled water group（ P < 0. 01）; the Xiaoyin Jiedu Granules group had the highest early apoptosis rate

which was significantly higher than that in Liangxuefang group

Jiedufang group

Acitretin group and distilled water group（ P < 0. 05 or P < 0. 01）. Conclusion Xiaoyin Jiedu Granules and its decomposed recipes could inhibit the inflammatory pathological model of psoriasis T cell abnormal proliferation

and the inhibitory effects of Xiaoyin Jiedu Granules and Liangxuefang seem better than Acitretin.