Objective To observe clinical curative effect of acrid-opening and bitter-downbearing method in treating laryngopharyngeal refulx disease. Methods Randomly divided 60 patients with laryngopharyngeal reflux disease into treatment group and control group

with 30 cases in each group. The treatment group was treated with acridopening and bitter-downbearing method

given modified Banxia Xiexin Decoction（ 半夏泻心汤） combined with Sini Powder（ 四逆散）

1 dose daily. The control group received Lansoprazole Orally Disintegrating Tablets 20 mg each time

twice a day. Evaluated objective and subjective curative effect after 4 weeks. Before and after treatment

respectively evaluated the reflux symptom index scale（ RSI） and the gastroesophageal reflux disease questionnaire（ Gerd Q） score. Results Symptom scores of RSI in both groups after treatment all significantly decreased compared with those before treatment

with hoarseness scores in the treatment group after treatment significantly lower than those in the control group（ P < 0. 05）. After treatment

Gerd Q acid reflux

heartburn

insomnia scores in the two groups were significantly lower than that before treatment. Acid reflux scores in the treatment group after treatment were significantly lower than the control group（ P < 0. 05）. The total effective rate of objective curative effect in the treatment group was 96. 67%

and the total effective rate of the subjective curative effect was 96. 67%

with the control group 90% and 83. 33% respectively. The subjective curative effect in the treatment group was better than the control group（ P < 0. 05）. There was no significant difference in objective curative effect between the two groups（ P >0. 05）. Conclusion Acrid-opening and bitter-downbearing method was superior to Lansoprazole Orally Disintegrating Tablets in improving subjective symptoms of patients with laryngopharyngeal refulx disease

especially in hoarseness and acid reflux.