Objective To explore the possible mechanism of Banxia Baizhu Tianma Tang（ 半夏白术天麻汤

BBTT） in treating hypertension of excessive accumulation of phlegm-dampness type. Methods The rats were given high fat diet for 24 weeks to build hypertension model of phlegm-dampness excessive accumulation type

and 16 successfully modelled rats were randomized into model group and BBTT group

and 8 rats with standard diet were set as the control group. BBTT group was given BBTT 13. 8 g/（ kg·d） by gavage for 12 weeks

while the control group and the model group were given normal saline of the same volume. The researchers recorded the weight

blood pressure

calculated Lee’s index

and detected the serum glucose

triglyceride and total cholesterol levels. The specimens were separated by dielectrophoresis and stained by silver nitrate

and hypothalamic differential protein spots were screened for protein identification by MALDI-TOF-TOF mass spectrometer and peptide mass fingerprinting

and some protein spots were selected to verify the results of proteomics. Results The weight

blood pressure

Lee’s index and total cholesterol level in the BBTT group were significantly lower than those in the model group（ P < 0. 05）. As for the protein spots

3342

3844

3828 were separated respectively in the control group

model group and BBTT group.Compared with the model group

the expressions of 100 proteins in the BBTT group were lower

and 72 higher. As for the 19 proteins with further identification by mass spectrometer

there were difference between the model group and the control group

while the BBTT group could reverse the difference trend of 11 of them

including 5 up-regulations and 6 down-regulations. Conclusion In treating hypertension of phlegm-dampness excessive accumulation type

BBTT might improve cytoskeletion and cellular morphology

endoplasmic reticulum stress

energy metabolism and neuron model.