Objective To explore the distribution feature of Chinese medicine constitution type in patients with chronic hepatitis B in different immune states

alanine aminotransferase（ ALT） levels

hepatitis B virus Deoxyribonucleic acid（ HBV DNA） viral load and hepatitis B e antigen（ HBe Ag） states. Methods One hundred and twentynine 129 patients with chronic hepatitis B were divided into an immunotolerant phase group（ 55 cases）

an immune clearance phase group（ 53 cases） and a low replication phase group（ 21 cases） according to immune state. Chinese medicine constitution types were judged by questionnaire survey. Relative laboratory indexes of patients were recorded. Distribution feature of Chinese medicine constitution types in different immune states

ALT level

HBV DNA viral load and HBe Ag states were analyzed and compared. Results All the constitution types in 129 patients appeared for 401 times in total

including the immunotolerant phase 141 times

the immune clearance phase 194 times

and the low replication phase 66 times. Based on their incidence

constitution types were ranked in order as Qi deficiency（ 18. 7%）

Yang deficiency（ 15. 2%）

dampness and heat（ 12. 5%）

phlegm and dampness（ 12. 2%）

moderate constitution（ 11. 5%）

Yin deficiency（ 10. 2%）

Qi stagnation（ 8. 7%）

blood stasis（ 7. 7%） and intrinsic constitution（ 3. 2%）. There were significant differences in distribution of 9 constitution types between different immune states groups. There were most moderate constitution types distributed in immunotolerant phase（ 21. 3%）

and most Qi deficiency types distributed in immune clearance phase（ 22. 2%） and low replication phase（ 21. 2%）（ P < 0. 05）. There were significant differences in Chinese medicine constitution distribution between the patients with different ALT levels（ P < 0. 05）. But there were no significant differences in Chinese medicine constitution distribution between patients with different HBV DNA viral load and HBe Ag states（ P > 0. 05）. Conclusion Immune states of patients with chronic hepatitis B show definite effect on their Chinese medicine constitution. In immunotolerant phase

moderate constitution is more often seen

while Qi deficiency constitution is more common in immune clearance phase and low replication phase.