Objective To explore the correlation between the phlegm-dampness constitution and the apolipoprotein E（ ApoE） gene polymorphism in stroke patients. Methods Seventy-seven stroke patients of the phlegmdampness constitution were brought into the observation group

eighty stroke patients of not-phlegm-dampness constitution into the control group. The general information of the patients was collected

while their blood lipid level and apolipoprotein level were detected

including triglyceride（ TG）

total cholesterol（ TC）

high-density lipoprotein cholesterol（ HDL-C）

low-density lipoprotein cholesterol（ LDL-C）

apolipoprotein A1（ ApoA1）

apolipoprotein B（ ApoB）

lipoprotein（ a） [Lp（ a） ]

ApoE

as well as the gene polymorphism of ApoE. Results Compared with those in the control group

the TC

TG

LDL-C

ApoE and ApoB levels in the observation group all increased

while the HDL-C level and ApoA1/ApoB decreased（ P < 0. 05 or P < 0. 01）

and there’ s no significant statistical differences of Lp（ a） and ApoA1 levels（ P > 0. 05）. In total three genotypes（ ε3/ ε3

ε2/ ε3

ε3/ ε4） and three alleles（ ε2

ε3

ε4） were detected. There was no significant statistical difference in genotype and allele distribution between these two groups by Hardy-Weinberg equilibrium test（ P > 0. 05）

which was consistent with the Hardy-Weinberg equilibrium. The distribution of ApoE genotype and its allele in the two groups were statistically significant（ P <0. 05）. Compared with the control group

there were more ApoE ε4 allele and ApoE ε3/ ε4 genotype in the observation group（ P < 0. 05）

while for other genotypes and alleles

there was no significant difference between the two groups（ P > 0. 05）. Conclusion The tendency to stroke among stroke patients of phlegm-dampness constitution might be associated with ApoE ε4 allele and ApoE ε3/ ε4 genotype

and the high blood lipid concentration of people with phlegm-dampness constitution might be regulated by ApoE gene polymorphism.