Effect of Chinese Herbs for Clearing Liver and Nourishing Kidney on Serum Inflammatory Factors in High-Fat Fed Spontaneous Hypertensive Rats

ZHANG Xiaoxiao; YIN Xiaowei; YAN Yu; JIANG Weimin

doi:10.13288/j.11-2166/r.2017.15.014

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Effect of Chinese Herbs for Clearing Liver and Nourishing Kidney on Serum Inflammatory Factors in High-Fat Fed Spontaneous Hypertensive Rats

更新时间：2021-11-10

- Effect of Chinese Herbs for Clearing Liver and Nourishing Kidney on Serum Inflammatory Factors in High-Fat Fed Spontaneous Hypertensive Rats
- Journal of Traditional Chinese Medicine Vol. 58, Issue 15, Pages: 1316-1318(2017)
- 作者机构：
  
  1. 南京中医药大学
  2. 江苏省中医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2017.15.014
  CLC： R285.5
- Published：2017
- 稿件说明：
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[1]张箫箫,殷晓威,严羽,蒋卫民.清肝滋肾中药对高脂喂养自发性高血压大鼠血清炎症因子的影响[J].中医杂志,2017,58(15):1316-1318.

ZHANG Xiaoxiao, YIN Xiaowei, YAN Yu, et al. Effect of Chinese Herbs for Clearing Liver and Nourishing Kidney on Serum Inflammatory Factors in High-Fat Fed Spontaneous Hypertensive Rats[J]. Journal of Traditional Chinese Medicine2017, 58(15): 1316-1318.
[1]张箫箫,殷晓威,严羽,蒋卫民.清肝滋肾中药对高脂喂养自发性高血压大鼠血清炎症因子的影响[J].中医杂志,2017,58(15):1316-1318. DOI： 10.13288/j.11-2166/r.2017.15.014.

ZHANG Xiaoxiao, YIN Xiaowei, YAN Yu, et al. Effect of Chinese Herbs for Clearing Liver and Nourishing Kidney on Serum Inflammatory Factors in High-Fat Fed Spontaneous Hypertensive Rats[J]. Journal of Traditional Chinese Medicine2017, 58(15): 1316-1318. DOI： 10.13288/j.11-2166/r.2017.15.014.

摘要

目的探讨清肝滋肾中药治疗原发性高血压病合并代谢紊乱的可能作用机制。方法 18只自发性高血压大鼠随机分为正常组、模型组和中药组

每组6只。正常组在普通饲料喂养基础上予0.5%纤维素钠安慰剂1 ml灌胃

模型组在高脂饲料喂养基础上予0.5%纤维素钠安慰剂1 ml灌胃

中药组在高脂饲料喂养基础上给予清肝滋肾中药22.5 g/（kg·d）混悬液灌胃

各组均灌胃8周。灌胃4周及8周时

测定血清中血管紧张素Ⅱ（AngⅡ）、肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）、单核细胞趋化蛋白1（MCP-1）、人纤溶酶原激活物抑制1（PAI-1）水平。结果高脂喂养后即8周时模型组大鼠血清AngⅡ、TNF-α、IL-6、PAI-1水平较正常组均显著升高。而给予清肝滋肾中药干预后

与模型组比较

中药组大鼠血清AngⅡ、TNF-α、IL-6、PAI-1水平显著降低

其中IL-6与正常组差异无统计学意义（P>0.05）

TNF-α显著低于正常组

PAI-1显著高于正常组（P<0.05）。结论清肝滋肾中药可以抑制高脂喂养自发性高血压大鼠炎症因子的表达

可能是其治疗高血压病合并代谢紊乱作用机制之一。

Abstract

Objective To explore the possible functional mechanism of clearing liver and nourishing kidney Chinese herbs in treating primary hypertension with metabolic disorder. Methods Randomly divided 18 spontaneous hypertensive rats into normal group

model group and Chinese medicine group

with 6 rats in each. The normal group was given 0. 5% sodium cellulose placebo 1ml for gavage in addition to standard diet. The model group was given0. 5% sodium cellulose placebo 1ml for gavage in addition to high fat diet. The Chinese medicine group was given suspension of clearing liver and nourishing kidney Chinese herbs 22. 5 g/（ kg·d） for gavage in addition to high fat diet. Each group was gavaged for 8 weeks. Measured the levels of angiotensinⅡ（ AngⅡ）

tumor necrosis factor α（ TNF-α）

interleukin 6（ IL-6）

monocyte chemoattractant protein 1（ MCP-1）

and human plasminogen activator inhibitor 1（ PAI-1） at the 4th and the 8th week of gavage. Results After being fed with high fat diet

serum AngⅡ

TNF-α

IL-6 and PAI-1 levels of rats in the model group all remarkably increased compared with those of the normal group. Compared with the model group

serum AngⅡ

TNF-α

IL-6 and PAI-1 levels of rats in the Chinese medicine group remarkably decreased after receiving clearing liver and nourishing kidney Chinese herbs. Among them

the difference of IL-6 level between the Chinese medicine and the normal group was not statistically significant（ P >0. 05）

with TNF-α remarkably lower than the normal group and PAI-1 remarkably higher than the normal group（ P < 0. 05）. Conclusion Chinese herbs for clearing liver and nourishing kidney could inhibit expression of inflammatory factors in high-fat fed spontaneous hypertensive rats. This might be one of the functional mechanism in treating hypertension with metabolic disorders.

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