Objective To evaluate the efficacy and safety of sublingual Tongqiao Jiuxin You（ 通窍救心油

TJY）in treating unstable angina. Methods Totally 118 patients with unstable angina were selected

and they were randomized into a sublingual group（ 30 cases）

an oral group（ 29 cases）

a topical application group（ 31 cases） and a control group（ 28 cases）. In addition to the standard western medicine treatment

the sublingual group was given sublingual TJY

while the oral group was given oral TJY

the topical application group TJY externally applied to point Renzhong（ DU26） and the control group was given oral Isosorbide Dinitrate Tablets. All patients could additionally take the same medicine when angina attacked. All groups were treated for 7 days. Before and after treatment

weekly angina attack number

chest pain score and chest tightness score were observed. The efficacy of angina remission time and electrocardiogram（ ECG） efficacy and safety were evaluated after treatment. Results After treatment

the weekly angina attack number

chest pain score

chest tightness score

efficacy of angina remission time and ECG efficacy in each group were all improved significantly than before（ P < 0. 05）. There was no significant difference in total effective rate of angina remission time between the sublingual group and the oral group

the topical application group and the control group. Compared with those in the oral group and the topical application group

the weekly angina attack number

chest pain score

chest tightness score

efficacy of angina remission time and ECG efficacy in the sublingual group were significant better（ P < 0. 0167）

while there were the equal effecy in the weekly angina attack number

chest pain score

chest tightness score

efficacy of angina remission time and ECG efficacy between the sublingual group and the control group. There were no differences in the abnormal results of liver and kidney function

as well as the blood

urine and stool routine tests between before and after treatment in all groups. Conclusion Sublingual TJY in the treatment of unstable angina seems effective and safe. It seems equivalent to Isosorbide Dinitrate Tablets in rapidly relieving angina

reducing the number of angina attacks

reducing chest pain and chest tightness degrees and improving myocardial ischemia showed in ECG. The effective time in the sublingual administration seems better than the topical application and the oral administration.